Multiple-turnover single nucleotide primer extension reactions to detect 8-oxo-2′-deoxyguanosine in DNA

Yoshiya Kikukawa, Ryoji Kawazoe, Ryo Miyahara, Takato Sakurada, Yusuke Nagata, Shigeki Sasaki, Yosuke Taniguchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The identification of the position of 8-oxo-2′-deoxyguanosine (8-oxo-dG) in DNA is important to clarify the pathogenesis of many diseases. We herein developed a purine-1,3-diazaphenoxazine triphosphate (dPdapTP) and described the first example of detecting the presence of 8-oxo-dG by amplifying it several hundred times after the multiple-turnover single nucleotide primer extension reactions.

Original languageEnglish
Pages (from-to)5399-5402
Number of pages4
JournalChemical Communications
Volume58
Issue number35
DOIs
Publication statusPublished - Apr 8 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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