Mural nodule in branch duct-type intraductal papillary mucinous neoplasms of the pancreas is a marker of malignant transformation and indication for surgery

Hirofumi Akita, Yutaka Takeda, Hiromitsu Hoshino, Hiroshi Wada, Shogo Kobayashi, Shigeru Marubashi, Hidetoshi Eguchi, Masahiro Tanemura, Masaki Mori, Yuichiro Doki, Hiroaki Nagano

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: The management of branch duct-type intraductal papillary mucinous neoplasms (IPMNs) remains controversial. This study aimed to elucidate the preoperative clinical factors that identify high-risk malignant transformation in branch duct-type IPMN. Methods: We retrospectively evaluated 38 patients diagnosed with branch duct-type IPMN who underwent pancreatectomy, identifying different preoperative factors between adenoma (intraductal papillary mucinous adenoma [IPMA]) and carcinoma (intraductal papillary mucinous carcinoma [IPMC]). Results: Twelve patients were diagnosed with IPMC. The mean tumor size was 31.9 ± 11.8 mm for IPMA and 35.7 ± 17.1 mm for IPMC (P = .467). No significant differences were found between IPMA and IPMC patients with regard to age, sex, symptoms, and tumor number. The mean diameter of the main pancreatic duct was significantly larger in IPMCs (8.3 ± 5.9 mm) compared with IPMAs (4.7 ± 2.3 mm; P = .011). The mural nodule was a good predictor of malignancy (P = .0002) and was identified as the only independent and significant marker of IPMC in multivariate analysis. Conclusions: The presence of mural nodules is a potentially suitable marker for differentiating IPMC from IPMA, and is important for making decisions about surgical interventions.

Original languageEnglish
Pages (from-to)214-219
Number of pages6
JournalAmerican Journal of Surgery
Volume202
Issue number2
DOIs
Publication statusPublished - Aug 1 2011
Externally publishedYes

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Mucinous Adenocarcinoma
Carcinoma, Intraductal, Noninfiltrating
Papillary Carcinoma
Pancreatic Neoplasms
Adenoma
Neoplasms
Pancreatectomy
Pancreatic Ducts
Decision Making
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery

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Mural nodule in branch duct-type intraductal papillary mucinous neoplasms of the pancreas is a marker of malignant transformation and indication for surgery. / Akita, Hirofumi; Takeda, Yutaka; Hoshino, Hiromitsu; Wada, Hiroshi; Kobayashi, Shogo; Marubashi, Shigeru; Eguchi, Hidetoshi; Tanemura, Masahiro; Mori, Masaki; Doki, Yuichiro; Nagano, Hiroaki.

In: American Journal of Surgery, Vol. 202, No. 2, 01.08.2011, p. 214-219.

Research output: Contribution to journalArticle

Akita, Hirofumi ; Takeda, Yutaka ; Hoshino, Hiromitsu ; Wada, Hiroshi ; Kobayashi, Shogo ; Marubashi, Shigeru ; Eguchi, Hidetoshi ; Tanemura, Masahiro ; Mori, Masaki ; Doki, Yuichiro ; Nagano, Hiroaki. / Mural nodule in branch duct-type intraductal papillary mucinous neoplasms of the pancreas is a marker of malignant transformation and indication for surgery. In: American Journal of Surgery. 2011 ; Vol. 202, No. 2. pp. 214-219.
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