Murine model of IgE production with a predominant Th2-response by feeding protein antigen without adjuvants

Kazue Ito, Kyoko Inagaki-Ohara, Shinji Murosaki, Hitoshi Nishimura, Tomoya Shimokata, Shinnpei Torii, Tukasa Matsuda, Yasunobu Yoshikai

    Research output: Contribution to journalArticlepeer-review

    36 Citations (Scopus)

    Abstract

    Stimulation of systemic antigen-specific IgE production plays an important role in the mediation of food allergy; however, the mechanism of IgE production against food antigens is not fully understood. The development of relevant animal models may help to elucidate the pathogenesis of food allergy. We here show that DBA/2 mice receiving a casein diet without any adjuvant produced high levels of IgE specific for casein, accompanied by predominant Th2-like responses in liver lymphocytes, mesenteric lymph node cells and spleen cells. This model of IgE production produced by feeding protein antigen as a constituent of the diet can be applied to investigate the mechanism of IgE production and to develop reagents for controlling food allergy.

    Original languageEnglish
    Pages (from-to)3427-3437
    Number of pages11
    JournalEuropean Journal of Immunology
    Volume27
    Issue number12
    DOIs
    Publication statusPublished - Dec 1 1997

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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