Muscarinic acetylcholine receptor subtypes in the human iris

Nobuto Ishizaka, Mami Noda, Shigeru Yokoyama, Kazuo Kawasaki, Miyuki Yamamoto, Haruhiro Higashida

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Abstract

Employing subtype-specific antisera, we measured the relative immunoreactivity of five muscarinic acetylcholine receptor (mAChR) subtype proteins (m1-m5) in the human iris. The most intensive FITC immunofluorescence was detected by the anti-m3 antibody, followed by anti-ml and -m5 antisera, in the iris sphincter muscle cells. Only very weak fluorescence was obtained by anti-m2 and -m4 antibodies. In dilator muscle cells, weak but not consistent immunoreactivity was found by anti-ml and -m5 antibodies. The results suggest that the m3 muscarinic receptor is the predominant subtype in sphincter muscle cells of the human iris.

Original languageEnglish
Pages (from-to)344-347
Number of pages4
JournalBrain Research
Volume787
Issue number2
DOIs
Publication statusPublished - Mar 23 1998
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Ishizaka, N., Noda, M., Yokoyama, S., Kawasaki, K., Yamamoto, M., & Higashida, H. (1998). Muscarinic acetylcholine receptor subtypes in the human iris. Brain Research, 787(2), 344-347. https://doi.org/10.1016/S0006-8993(97)01554-0