Abstract
Employing subtype-specific antisera, we measured the relative immunoreactivity of five muscarinic acetylcholine receptor (mAChR) subtype proteins (m1-m5) in the human iris. The most intensive FITC immunofluorescence was detected by the anti-m3 antibody, followed by anti-ml and -m5 antisera, in the iris sphincter muscle cells. Only very weak fluorescence was obtained by anti-m2 and -m4 antibodies. In dilator muscle cells, weak but not consistent immunoreactivity was found by anti-ml and -m5 antibodies. The results suggest that the m3 muscarinic receptor is the predominant subtype in sphincter muscle cells of the human iris.
Original language | English |
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Pages (from-to) | 344-347 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 787 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 23 1998 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Neuroscience(all)