Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice

Takeshi Yokoyama, Tammy L. Lisi, Steven A. Moore, Kathleen A. Sluka

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Chronic muscle pain is a major clinical problem that is often associated with fatigue. Conversely, chronic fatigue conditions are commonly associated with muscle pain. We tested the hypothesis that muscle fatigue enhances hyperalgesia associated with injection of acidic saline into muscle. We evaluated mechanical sensitivity of the paw (von Frey) in mice after 2 intramuscular injections of saline (20 μL; pH 4, pH 5, pH 6, pH 7.2) in a fatigue and a control group. To induce fatigue, mice were run for 2 h/day for 2 days prior to the first injection and 2 h/day for 2 days prior to the second injection. Muscle lactate, pCO2, pO2, creatinine kinase, phosphate, and histology were examined after the fatigue task and compared to a control group. Grip force was significantly decreased after 2 h of running indicating fatigue. The fatigue task did not induce muscle damage as there was no difference in muscle lactate, pCO2, pO2, creatinine kinase, phosphate, or histology. The fatigue task altered the dose-response relationship to intramuscular acidic saline injections. Mechanical hyperalgesia was observed in both fatigue and control groups after intramuscular injection of pH 4.0, but only the fatigue group after injection of pH 5. Neither the fatigue nor the control group developed hyperalgesia in response to intramuscular injection of pH 6 or pH 7.2. In conclusion, fatigue modified the susceptibility of mice to acid injection of pH 5.0 to result in mechanical hyperalgesia after 2 injections of pH 5.0. The fatigue task did not produce measurable changes in the muscle tissue suggesting a central mechanism mediating the enhancement of hyperalgesia. Perspective: These data therefore show that muscle fatigue can enhance the likelihood that one develops pain to a mild insult. Clinically, this could relate to the development of pain from such conditions as repetitive strain injury, and may relate to the interrelationship between chronic pain and fatigue.

Original languageEnglish
Pages (from-to)692-699
Number of pages8
JournalJournal of Pain
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 1 2007
Externally publishedYes

Fingerprint

Muscle Fatigue
Hyperalgesia
Fatigue
Injections
Intramuscular Injections
Muscles
Control Groups
Myalgia
Chronic Pain
Lactic Acid
Creatinine
Histology
Phosphotransferases
Phosphates
Cumulative Trauma Disorders
Pain
Hand Strength
Running

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice. / Yokoyama, Takeshi; Lisi, Tammy L.; Moore, Steven A.; Sluka, Kathleen A.

In: Journal of Pain, Vol. 8, No. 9, 01.09.2007, p. 692-699.

Research output: Contribution to journalArticle

Yokoyama, Takeshi ; Lisi, Tammy L. ; Moore, Steven A. ; Sluka, Kathleen A. / Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice. In: Journal of Pain. 2007 ; Vol. 8, No. 9. pp. 692-699.
@article{29119a686366457a96518d6b418fe828,
title = "Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice",
abstract = "Chronic muscle pain is a major clinical problem that is often associated with fatigue. Conversely, chronic fatigue conditions are commonly associated with muscle pain. We tested the hypothesis that muscle fatigue enhances hyperalgesia associated with injection of acidic saline into muscle. We evaluated mechanical sensitivity of the paw (von Frey) in mice after 2 intramuscular injections of saline (20 μL; pH 4, pH 5, pH 6, pH 7.2) in a fatigue and a control group. To induce fatigue, mice were run for 2 h/day for 2 days prior to the first injection and 2 h/day for 2 days prior to the second injection. Muscle lactate, pCO2, pO2, creatinine kinase, phosphate, and histology were examined after the fatigue task and compared to a control group. Grip force was significantly decreased after 2 h of running indicating fatigue. The fatigue task did not induce muscle damage as there was no difference in muscle lactate, pCO2, pO2, creatinine kinase, phosphate, or histology. The fatigue task altered the dose-response relationship to intramuscular acidic saline injections. Mechanical hyperalgesia was observed in both fatigue and control groups after intramuscular injection of pH 4.0, but only the fatigue group after injection of pH 5. Neither the fatigue nor the control group developed hyperalgesia in response to intramuscular injection of pH 6 or pH 7.2. In conclusion, fatigue modified the susceptibility of mice to acid injection of pH 5.0 to result in mechanical hyperalgesia after 2 injections of pH 5.0. The fatigue task did not produce measurable changes in the muscle tissue suggesting a central mechanism mediating the enhancement of hyperalgesia. Perspective: These data therefore show that muscle fatigue can enhance the likelihood that one develops pain to a mild insult. Clinically, this could relate to the development of pain from such conditions as repetitive strain injury, and may relate to the interrelationship between chronic pain and fatigue.",
author = "Takeshi Yokoyama and Lisi, {Tammy L.} and Moore, {Steven A.} and Sluka, {Kathleen A.}",
year = "2007",
month = "9",
day = "1",
doi = "10.1016/j.jpain.2007.05.008",
language = "English",
volume = "8",
pages = "692--699",
journal = "Journal of Pain",
issn = "1526-5900",
publisher = "PS journal 刊行委員会",
number = "9",

}

TY - JOUR

T1 - Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice

AU - Yokoyama, Takeshi

AU - Lisi, Tammy L.

AU - Moore, Steven A.

AU - Sluka, Kathleen A.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Chronic muscle pain is a major clinical problem that is often associated with fatigue. Conversely, chronic fatigue conditions are commonly associated with muscle pain. We tested the hypothesis that muscle fatigue enhances hyperalgesia associated with injection of acidic saline into muscle. We evaluated mechanical sensitivity of the paw (von Frey) in mice after 2 intramuscular injections of saline (20 μL; pH 4, pH 5, pH 6, pH 7.2) in a fatigue and a control group. To induce fatigue, mice were run for 2 h/day for 2 days prior to the first injection and 2 h/day for 2 days prior to the second injection. Muscle lactate, pCO2, pO2, creatinine kinase, phosphate, and histology were examined after the fatigue task and compared to a control group. Grip force was significantly decreased after 2 h of running indicating fatigue. The fatigue task did not induce muscle damage as there was no difference in muscle lactate, pCO2, pO2, creatinine kinase, phosphate, or histology. The fatigue task altered the dose-response relationship to intramuscular acidic saline injections. Mechanical hyperalgesia was observed in both fatigue and control groups after intramuscular injection of pH 4.0, but only the fatigue group after injection of pH 5. Neither the fatigue nor the control group developed hyperalgesia in response to intramuscular injection of pH 6 or pH 7.2. In conclusion, fatigue modified the susceptibility of mice to acid injection of pH 5.0 to result in mechanical hyperalgesia after 2 injections of pH 5.0. The fatigue task did not produce measurable changes in the muscle tissue suggesting a central mechanism mediating the enhancement of hyperalgesia. Perspective: These data therefore show that muscle fatigue can enhance the likelihood that one develops pain to a mild insult. Clinically, this could relate to the development of pain from such conditions as repetitive strain injury, and may relate to the interrelationship between chronic pain and fatigue.

AB - Chronic muscle pain is a major clinical problem that is often associated with fatigue. Conversely, chronic fatigue conditions are commonly associated with muscle pain. We tested the hypothesis that muscle fatigue enhances hyperalgesia associated with injection of acidic saline into muscle. We evaluated mechanical sensitivity of the paw (von Frey) in mice after 2 intramuscular injections of saline (20 μL; pH 4, pH 5, pH 6, pH 7.2) in a fatigue and a control group. To induce fatigue, mice were run for 2 h/day for 2 days prior to the first injection and 2 h/day for 2 days prior to the second injection. Muscle lactate, pCO2, pO2, creatinine kinase, phosphate, and histology were examined after the fatigue task and compared to a control group. Grip force was significantly decreased after 2 h of running indicating fatigue. The fatigue task did not induce muscle damage as there was no difference in muscle lactate, pCO2, pO2, creatinine kinase, phosphate, or histology. The fatigue task altered the dose-response relationship to intramuscular acidic saline injections. Mechanical hyperalgesia was observed in both fatigue and control groups after intramuscular injection of pH 4.0, but only the fatigue group after injection of pH 5. Neither the fatigue nor the control group developed hyperalgesia in response to intramuscular injection of pH 6 or pH 7.2. In conclusion, fatigue modified the susceptibility of mice to acid injection of pH 5.0 to result in mechanical hyperalgesia after 2 injections of pH 5.0. The fatigue task did not produce measurable changes in the muscle tissue suggesting a central mechanism mediating the enhancement of hyperalgesia. Perspective: These data therefore show that muscle fatigue can enhance the likelihood that one develops pain to a mild insult. Clinically, this could relate to the development of pain from such conditions as repetitive strain injury, and may relate to the interrelationship between chronic pain and fatigue.

UR - http://www.scopus.com/inward/record.url?scp=34548455349&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548455349&partnerID=8YFLogxK

U2 - 10.1016/j.jpain.2007.05.008

DO - 10.1016/j.jpain.2007.05.008

M3 - Article

C2 - 17627895

AN - SCOPUS:34548455349

VL - 8

SP - 692

EP - 699

JO - Journal of Pain

JF - Journal of Pain

SN - 1526-5900

IS - 9

ER -