Although standing-up motion is an important activity of daily living, it remains unclear how people perform the motion in different situations. As described in this paper, muscle synergy analysis is applied to standing-up motions performed at different circumstances, such as two different heights and at three different speeds. Results elucidated three invariant groups of synchronized muscle activations: The first synergy pulls the ankle and raises the hip. The second synergy extends the upper body. The third synergy stabilizes posture. Results also show that people controlled the activation coefficient of each synergy differently during all motions. The slower the standing-up motion is, the longer each synergy activates to adapt to the slower motion speed. Results of this study show that people use the same group of synchronized muscle activation and only control the activation coefficient to achieve adaptive standing-up motion.