Mutation analysis of the base-pair connecting two functional modules in the DSL ribozyme.

Junya Ishikawa, Hiroyuki Furuta, Yoshiya Ikawa

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    The class DSL ribozyme is one of artificial RNA enzymes generated by module-based molecular design. In the structure of this ribozyme, two most important functional modules are connected by a U-A base-pair. We have examined the possible importance of this base-pair by site-directed mutation experiments using the DSL-1S ribozyme and its derivative possessing altered modular organization. The analysis indicated that the DSL-1S ribozyme preferred U-A pair at the positions whereas the derivative preferred A-U pair.

    Original languageEnglish
    Pages (from-to)523-524
    Number of pages2
    JournalNucleic acids symposium series (2004)
    Issue number52
    Publication statusPublished - Dec 1 2008

    All Science Journal Classification (ASJC) codes

    • Medicine(all)

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