Mutational landscape and clonal architecture in grade II and III gliomas

Hiromichi Suzuki, Kosuke Aoki, Kenichi Chiba, Yusuke Sato, Yusuke Shiozawa, Yuichi Shiraishi, Teppei Shimamura, Atsushi Niida, Kazuya Motomura, Fumiharu Ohka, Takashi Yamamoto, Kuniaki Tanahashi, Melissa Ranjit, Toshihiko Wakabayashi, Tetsuichi Yoshizato, Keisuke Kataoka, Kenichi Yoshida, Yasunobu Nagata, Aiko Sato-Otsubo, Hiroko TanakaMasashi Sanada, Yutaka Kondo, Hideo Nakamura, Masahiro Mizoguchi, Tatsuya Abe, Yoshihiro Muragaki, Reiko Watanabe, Ichiro Ito, Satoru Miyano, Atsushi Natsume, Seishi Ogawa

Research output: Contribution to journalArticle

310 Citations (Scopus)

Abstract

Grade II and III gliomas are generally slowly progressing brain cancers, many of which eventually transform into more aggressive tumors. Despite recent findings of frequent mutations in IDH1 and other genes, knowledge about their pathogenesis is still incomplete. Here, combining two large sets of high-throughput sequencing data, we delineate the entire picture of genetic alterations and affected pathways in these glioma types, with sensitive detection of driver genes. Grade II and III gliomas comprise three distinct subtypes characterized by discrete sets of mutations and distinct clinical behaviors. Mutations showed significant positive and negative correlations and a chronological hierarchy, as inferred from different allelic burdens among coexisting mutations, suggesting that there is functional interplay between the mutations that drive clonal selection. Extensive serial and multi-regional sampling analyses further supported this finding and also identified a high degree of temporal and spatial heterogeneity generated during tumor expansion and relapse, which is likely shaped by the complex but ordered processes of multiple clonal selection and evolutionary events.

Original languageEnglish
Pages (from-to)458-468
Number of pages11
JournalNature genetics
Volume47
Issue number5
DOIs
Publication statusPublished - May 30 2015

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Glioma
Mutation
Brain Neoplasms
Genes
Neoplasms
Recurrence

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Suzuki, H., Aoki, K., Chiba, K., Sato, Y., Shiozawa, Y., Shiraishi, Y., ... Ogawa, S. (2015). Mutational landscape and clonal architecture in grade II and III gliomas. Nature genetics, 47(5), 458-468. https://doi.org/10.1038/ng.3273

Mutational landscape and clonal architecture in grade II and III gliomas. / Suzuki, Hiromichi; Aoki, Kosuke; Chiba, Kenichi; Sato, Yusuke; Shiozawa, Yusuke; Shiraishi, Yuichi; Shimamura, Teppei; Niida, Atsushi; Motomura, Kazuya; Ohka, Fumiharu; Yamamoto, Takashi; Tanahashi, Kuniaki; Ranjit, Melissa; Wakabayashi, Toshihiko; Yoshizato, Tetsuichi; Kataoka, Keisuke; Yoshida, Kenichi; Nagata, Yasunobu; Sato-Otsubo, Aiko; Tanaka, Hiroko; Sanada, Masashi; Kondo, Yutaka; Nakamura, Hideo; Mizoguchi, Masahiro; Abe, Tatsuya; Muragaki, Yoshihiro; Watanabe, Reiko; Ito, Ichiro; Miyano, Satoru; Natsume, Atsushi; Ogawa, Seishi.

In: Nature genetics, Vol. 47, No. 5, 30.05.2015, p. 458-468.

Research output: Contribution to journalArticle

Suzuki, H, Aoki, K, Chiba, K, Sato, Y, Shiozawa, Y, Shiraishi, Y, Shimamura, T, Niida, A, Motomura, K, Ohka, F, Yamamoto, T, Tanahashi, K, Ranjit, M, Wakabayashi, T, Yoshizato, T, Kataoka, K, Yoshida, K, Nagata, Y, Sato-Otsubo, A, Tanaka, H, Sanada, M, Kondo, Y, Nakamura, H, Mizoguchi, M, Abe, T, Muragaki, Y, Watanabe, R, Ito, I, Miyano, S, Natsume, A & Ogawa, S 2015, 'Mutational landscape and clonal architecture in grade II and III gliomas', Nature genetics, vol. 47, no. 5, pp. 458-468. https://doi.org/10.1038/ng.3273
Suzuki H, Aoki K, Chiba K, Sato Y, Shiozawa Y, Shiraishi Y et al. Mutational landscape and clonal architecture in grade II and III gliomas. Nature genetics. 2015 May 30;47(5):458-468. https://doi.org/10.1038/ng.3273
Suzuki, Hiromichi ; Aoki, Kosuke ; Chiba, Kenichi ; Sato, Yusuke ; Shiozawa, Yusuke ; Shiraishi, Yuichi ; Shimamura, Teppei ; Niida, Atsushi ; Motomura, Kazuya ; Ohka, Fumiharu ; Yamamoto, Takashi ; Tanahashi, Kuniaki ; Ranjit, Melissa ; Wakabayashi, Toshihiko ; Yoshizato, Tetsuichi ; Kataoka, Keisuke ; Yoshida, Kenichi ; Nagata, Yasunobu ; Sato-Otsubo, Aiko ; Tanaka, Hiroko ; Sanada, Masashi ; Kondo, Yutaka ; Nakamura, Hideo ; Mizoguchi, Masahiro ; Abe, Tatsuya ; Muragaki, Yoshihiro ; Watanabe, Reiko ; Ito, Ichiro ; Miyano, Satoru ; Natsume, Atsushi ; Ogawa, Seishi. / Mutational landscape and clonal architecture in grade II and III gliomas. In: Nature genetics. 2015 ; Vol. 47, No. 5. pp. 458-468.
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