Mutations of the p53 gene in malignant rhabdoid tumors of soft tissue and the kidney: Immunohistochemical and DNA direct sequencing analysis

Yoshiaki Kinoshita, Hideki Shiratsuchi, Sadafumi Tamiya, Yumi Oshiro, Yoichi Hachitanda, Yoshinao Oda, Sachiyo Suita, Masazumi Tsuneyoshi

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Malignant rhabdoid tumor (MRT) is characterized by the presence of intracytoplasmic eosinophilic inclusions composed of whorls of intermediate filaments. This tumor was originally described as an entity of the abortive type of Wilms' tumor in childhood. Recently, it has been proved that these rhabdoid cells can be observed in various types of malignant tumors, including soft tissue sarcoma or carcinoma. To investigate the oncogenesis of this tumor, we examined the p53 gene alteration by means of immunohistochemical analysis and DNA direct sequencing in three cases of malignant rhabdoid tumor (MRT) of the soft tissue and three cases of MRT of the kidney. All the cases of MRT of the soft tissue and two of the cases of MRT of the kidney showed immunopositivity for p53 protein. Among them, one of the cases of MRT of the soft tissue and two of the cases of MRT of the kidney showed missense mutations of the p53 gene. These results strongly suggest that p53 gene alterations may have an important role to play in the aggressive biological behavior and poor prognosis of this tumor.

Original languageEnglish
Pages (from-to)351-358
Number of pages8
JournalJournal of Cancer Research and Clinical Oncology
Volume127
Issue number6
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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