TY - JOUR
T1 - Myelitis with atopic diathesis
T2 - A nationwide survey of 79 cases in Japan
AU - Osoegawa, Manabu
AU - Ochi, Hirofumi
AU - Minohara, Motozumi
AU - Murai, Hiroyuki
AU - Umehara, Fujio
AU - Furuya, Hirokazu
AU - Yamada, Takeshi
AU - Kira, Jun Ichi
N1 - Funding Information:
This work was supported in part by grants from the Ministry of Education, Science, Sports and Culture of Japan, a grant from the Neuroimmunological Disease Research Committee and a Research on Brain Science grant from the Ministry of Health, Labour and Welfare of Japan.
PY - 2003/5/15
Y1 - 2003/5/15
N2 - We recently reported the occurrence of myelitis in patients with atopic disorders and its pathology to be eosinophilic inflammation. Because similar cases have been reported, we conducted a nationwide epidemiological survey (NES) of myelitis with atopy in Japan. We compared the clinicolaboratory features of the 30 NES cases with the 49 cases at Kyushu University Hospital (KU). Although the NES cases were distributed throughout Japan, the NES and KU cases shared common characteristics. We therefore combined all of the cases identified. The average onset age was 35.8±13.4 years, and the male/female ratio was 1:0.65. The onset mode was subacute/chronic in half the patients, and stepwise progression or symptom fluctuation was frequent (69.6%). The most common lesion site was determined clinically and by MRI to be the cervical cord, and paresthesia and/or dysesthesia were the most common symptoms initially (74.7%) and throughout the entire course (83.5%). Cerebrospinal fluid (CSF) abnormalities were infrequent and mild. These findings suggest that myelitis associated with atopy has mild but prolonged symptoms and occurs throughout Japan.
AB - We recently reported the occurrence of myelitis in patients with atopic disorders and its pathology to be eosinophilic inflammation. Because similar cases have been reported, we conducted a nationwide epidemiological survey (NES) of myelitis with atopy in Japan. We compared the clinicolaboratory features of the 30 NES cases with the 49 cases at Kyushu University Hospital (KU). Although the NES cases were distributed throughout Japan, the NES and KU cases shared common characteristics. We therefore combined all of the cases identified. The average onset age was 35.8±13.4 years, and the male/female ratio was 1:0.65. The onset mode was subacute/chronic in half the patients, and stepwise progression or symptom fluctuation was frequent (69.6%). The most common lesion site was determined clinically and by MRI to be the cervical cord, and paresthesia and/or dysesthesia were the most common symptoms initially (74.7%) and throughout the entire course (83.5%). Cerebrospinal fluid (CSF) abnormalities were infrequent and mild. These findings suggest that myelitis associated with atopy has mild but prolonged symptoms and occurs throughout Japan.
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U2 - 10.1016/S0022-510X(02)00441-0
DO - 10.1016/S0022-510X(02)00441-0
M3 - Article
C2 - 12686395
AN - SCOPUS:0037447743
SN - 0022-510X
VL - 209
SP - 5
EP - 11
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -