Myeloid Lineage Commitment from the Hematopoietic Stem Cell

Hiromi Iwasaki, Koichi Akashi

Research output: Contribution to journalReview article

251 Citations (Scopus)

Abstract

Prospective isolation of hematopoietic stem and progenitor cells has identified the lineal relationships among all blood-cell types and has allowed their developmental mechanisms to be assayed at the single-cell level. These isolated cell populations are used to elucidate the molecular mechanism of lineage fate decision and of its plasticity directly by stage-specific enforcement or repression of lineage-instructive signaling in purified cells. With an emphasis on the myeloid lineage, this review summarizes current concepts and controversies regarding adult murine hematopoietic development and discusses the potential mechanisms, operated by single or by multiple transcription factors, of myeloid lineage fate decision.

Original languageEnglish
Pages (from-to)726-740
Number of pages15
JournalImmunity
Volume26
Issue number6
DOIs
Publication statusPublished - Jun 22 2007

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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