Myocardial β-adrenergic receptor density assessed by 11C-CGP12177 PET predicts improvement of cardiac function after carvedilol treatment in patients with idiopathic dilated cardiomyopathy

Masanao Naya, Takahiro Tsukamoto, Koichi Morita, Chietsugu Katoh, Kenichi Nishijima, Hiroshi Komatsu, Satoshi Yamada, Yuji Kuge, Nagara Tamaki, Hiroyuki Tsutsui

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36 Citations (Scopus)

Abstract

We evaluated whether myocardial β-adrenergic receptor (β-AR) density, as determined by 11C-CGP12177 PET, could predict improvement of cardiac function by β-blocker carvedilol treatment in patients with idiopathic dilated cardiomyopathy (IDC). Methods: Ten patients with IDC (left ventricular ejection fraction [LVEF] < 45%) were studied. Myocardial β-AR density was estimated using 11C-CGP12177 PET before treatment with carvedilol. Changes of LVEF in response to dobutamine infusion (ΔLVEF-dobutamine) were also measured by echocardiography. Changes of LVEF (ΔLVEF-carvedilol) were evaluated after 20 mo of carvedilol treatment. Results: Baseline myocardial β-AR density significantly correlated with ΔLVEF-carvedilol (r = -0.88, P < 0.001). In contrast, ΔLVEF-dobutamine did not correlate with ΔLVEF-carvedilol (P = 0.65). Myocardial β-AR density was the significant multivariate independent predictor of ΔLVEF-carvedilol (β = -0.88, P < 0.001) among univariate predictors, including functional class (r = 0.76, P < 0.05), plasma norepinephrine (r = 0.85, P < 0.01), LVEF (r = -0.64, P < 0.05), and age as confounding factors. Furthermore, myocardial β-AR density was significantly correlated with plasma norepinephrine (r = -0.79, P < 0.01) and LVEF (r = 0.70, P < 0.05). Conclusion: Myocardial β-AR density is more tightly related to improvement of LVEF-carvedilol than is cardiac contractile reserve in patients with IDC. Patients with decreased myocardial β-AR have higher resting adrenergic drive, as reflected by plasma norepinephrine, and may receive greater benefit from being treated by antiadrenergic drugs. COPYRIGHT

Original languageEnglish
Pages (from-to)220-225
Number of pages6
JournalJournal of Nuclear Medicine
Volume50
Issue number2
DOIs
Publication statusPublished - Feb 1 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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