Myocardial oxidative metabolism is increased due to haemodynamic overload in patients with aortic valve stenosis: Assessment using 11C-acetate positron emission tomography

Masanao Naya, Satoru Chiba, Hiroyuki Iwano, Satoshi Yamada, Chietsugu Katoh, Osamu Manabe, Keiichiro Yoshinaga, Yoshiro Matsui, Nagara Tamaki, Hiroyuki Tsutsui

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Purpose: The relationship between myocardial oxidative metabolism and pressure overload in aortic valve stenosis (AS) is not fully elucidated. We identified the determinants of myocardial oxidative metabolism by measuring its changes after aortic valve replacement (AVR) in patients with AS. Methods: Myocardial 11C-acetate clearance rate constant (Kmono), an index of oxidative metabolism, was measured non-invasively by using positron emission tomography in 16 patients with moderate to severe AS and 7 healthy controls. The severity of AS was assessed by echocardiography. Of 16 patients, 5 were reexamined at 1 month after AVR. Results: Kmono was significantly higher in patients with AS than healthy controls by 42% (0.068±0.014 vs 0.048±0.007/min, p<0.01). Kmono was significantly correlated with age (r=0.58, p<0.01), left ventricular (LV) mass index (r=0.61, p<0.01) and estimated systolic LV pressure (r=0.81, p<0.001) measured by echocardiography. By multivariate analysis, estimated LV systolic pressure was an independent predictor of Kmono (β=0.93, p<0.01). After AVR, Kmono (from 0.075±0.012 to 0.061±0.014/min, p=0.043) and LV mass index (from 183±49 to 124±41 g/ml2, p=0.043) were significantly decreased despite no significant changes in rate-pressure product. Conclusion: Myocardial oxygen metabolism was increased in patients with AS, which was decreased after AVR. The increased myocardial oxidative metabolism in AS was largely attributable to the pressure overload of the LV.

Original languageEnglish
Pages (from-to)2242-2248
Number of pages7
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume37
Issue number12
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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