Myocardial shortening in 3 orthogonal directions and its transmural variation in patients with nonobstructive hypertrophic cardiomyopathy

Kazunori Okada, Satoshi Yamada, Hiroyuki Iwano, Hisao Nishino, Masahiro Nakabachi, Shinobu Yokoyama, Ayumu Abe, Ayako Ichikawa, Sanae Kaga, Mutsumi Nishida, Taichi Hayashi, Daisuke Murai, Taisei Mikami, Hiroyuki Tsutsui

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Background: Although longitudinal strain (LS) is known to be reduced in patients with hypertrophic cardiomyopathy (HCM), it has not been elucidated whether or not circumferential strain (CS) is reduced. We aimed to determine whether multidirectional and layer-specific myocardial strain is reduced in patients with nonobstructive HCM. Methods and Results: Speckle-tracking echocardiography was performed in 41 HCM patients and 27 control subjects. Segmental and global LS and CS were measured in the inner, mid, and outer layers. Global LS was significantly lower in the HCM group than in controls in the inner (−10.3±2.9 vs. −14.8±2.0%, P<0.001), mid (−8.7±2.6 vs. −13.8±1.9%, P<0.001), and outer (−7.2±2.6 vs. −11.9±1.9%, P<0.001) layers. Global CS was preserved in the inner layer (−23.8±4.7 vs. −24.3±3.3%, P=0.69) but reduced in the mid (−10.3±3.1 vs. −13.3±2.5%, P<0.001) and outer layers (−6.7±2.3 vs. −8.6±2.3%, P=0.002). Differences in CS between the inner and outer layers correlated with segmental relative wall thickness (r=−0.20, P=0.002). Furthermore, only the absolute value of global CS in the inner layer positively correlated with left ventricular ejection fraction (r=0.32, P<0.01) among these multidirectional and layer-specific strains. Conclusions: In patients with HCM, not only the LS in all layers but also CS in the mid and outer layers was reduced, presumably reflecting impaired myocardial function. In contrast, CS in the inner layer was preserved, being associated with maintenance of chamber function.

Original languageEnglish
Pages (from-to)2471-2479
Number of pages9
JournalCirculation Journal
Volume79
Issue number11
DOIs
Publication statusPublished - Oct 23 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Myocardial shortening in 3 orthogonal directions and its transmural variation in patients with nonobstructive hypertrophic cardiomyopathy'. Together they form a unique fingerprint.

Cite this