N-acetyl-L-cysteine inhibits marble-burying behavior in mice

Nobuaki Egashira, Atsunori Shirakawa, Moe Abe, Tomiko Niki, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

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Abstract

In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant á-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalJournal of Pharmacological Sciences
Volume119
Issue number1
DOIs
Publication statusPublished - May 30 2012

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Egashira, N., Shirakawa, A., Abe, M., Niki, T., Mishima, K., Iwasaki, K., ... Fujiwara, M. (2012). N-acetyl-L-cysteine inhibits marble-burying behavior in mice. Journal of Pharmacological Sciences, 119(1), 97-101. https://doi.org/10.1254/jphs.11228SC