TY - JOUR
T1 - N-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice
AU - Egashira, Nobuaki
AU - Shirakawa, Atsunori
AU - Abe, Moe
AU - Niki, Tomiko
AU - Mishima, Kenichi
AU - Iwasaki, Katsunori
AU - Oishi, Ryozo
AU - Fujiwara, Michihiro
PY - 2012/5/20
Y1 - 2012/5/20
N2 - In the present study, we examined the effect of <I>N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant <I>α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.
AB - In the present study, we examined the effect of <I>N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant <I>α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.
U2 - 10.1254/jphs.11228SC
DO - 10.1254/jphs.11228SC
M3 - Article
VL - 119
SP - 97
EP - 101
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 1
ER -