N-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice

Nobuaki Egashira; Atsunori Shirakawa; Moe Abe; Tomiko Niki; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara

doi:10.1254/jphs.11228SC

N-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice

Nobuaki Egashira, Atsunori Shirakawa, Moe Abe, Tomiko Niki, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

Pharmacy

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Abstract

In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	Journal of Pharmacological Sciences
Volume	119
Issue number	1
DOIs	https://doi.org/10.1254/jphs.11228SC
Publication status	Published - May 20 2012

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title = "N-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice",

abstract = "In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.",

author = "Nobuaki Egashira and Atsunori Shirakawa and Moe Abe and Tomiko Niki and Kenichi Mishima and Katsunori Iwasaki and Ryozo Oishi and Michihiro Fujiwara",

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T1 - N-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice

AU - Egashira, Nobuaki

AU - Shirakawa, Atsunori

AU - Abe, Moe

AU - Niki, Tomiko

AU - Mishima, Kenichi

AU - Iwasaki, Katsunori

AU - Oishi, Ryozo

AU - Fujiwara, Michihiro

PY - 2012/5/20

Y1 - 2012/5/20

N2 - In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.

AB - In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.

U2 - 10.1254/jphs.11228SC

DO - 10.1254/jphs.11228SC

M3 - Article

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SP - 97

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JO - Journal of Pharmacological Sciences

JF - Journal of Pharmacological Sciences

SN - 1347-8613

IS - 1

ER -

N-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice

Abstract

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