N-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice

Nobuaki Egashira, Atsunori Shirakawa, Moe Abe, Tomiko Niki, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study, we examined the effect of <I>N</I>-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant <I>α</I>-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.
Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalJournal of Pharmacological Sciences
Volume119
Issue number1
DOIs
Publication statusPublished - May 20 2012

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