N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

Yukiko Nisikawa, Takao Shimazoe, Shigenobu Shibata, Shigenori Watanabe

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.

Original languageEnglish
Pages (from-to)303-305
Number of pages3
JournalBrain Research
Volume782
Issue number1-2
DOIs
Publication statusPublished - Jan 26 1998
Externally publishedYes

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Suprachiasmatic Nucleus
Long-Term Potentiation
N-Methyl-D-Aspartate Receptors
6-Cyano-7-nitroquinoxaline-2,3-dione
Synaptic Potentials
Optic Nerve
Acids
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro. / Nisikawa, Yukiko; Shimazoe, Takao; Shibata, Shigenobu; Watanabe, Shigenori.

In: Brain Research, Vol. 782, No. 1-2, 26.01.1998, p. 303-305.

Research output: Contribution to journal › Article

Nisikawa, Y, Shimazoe, T, Shibata, S & Watanabe, S 1998, 'N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro', Brain Research, vol. 782, no. 1-2, pp. 303-305. https://doi.org/10.1016/S0006-8993(97)01177-3
Nisikawa Y, Shimazoe T, Shibata S, Watanabe S. N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro. Brain Research. 1998 Jan 26;782(1-2):303-305. https://doi.org/10.1016/S0006-8993(97)01177-3
Nisikawa, Yukiko ; Shimazoe, Takao ; Shibata, Shigenobu ; Watanabe, Shigenori. / N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro. In: Brain Research. 1998 ; Vol. 782, No. 1-2. pp. 303-305.
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