N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

Yukiko Nisikawa; Takao Shimazoe; Shigenobu Shibata; Shigenori Watanabe

doi:10.1016/S0006-8993(97)01177-3

N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

Yukiko Nisikawa, Takao Shimazoe, Shigenobu Shibata, Shigenori Watanabe

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.

Original language	English
Pages (from-to)	303-305
Number of pages	3
Journal	Brain Research
Volume	782
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(97)01177-3
Publication status	Published - Jan 26 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(97)01177-3

Cite this

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title = "N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro",

abstract = "Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.",

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T1 - N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

AU - Nisikawa, Yukiko

AU - Shimazoe, Takao

AU - Shibata, Shigenobu

AU - Watanabe, Shigenori

PY - 1998/1/26

Y1 - 1998/1/26

N2 - Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.

AB - Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.

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ER -

N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

Abstract

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