N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells

Yuichi Murakami, Kosuke Watari, Tomohiro Shibata, Manami Uba, Hiroki Ureshino, Akihiko Kawahara, Hideyuki Abe, Hiroto Izumi, Naofumi Mukaida, Michihiko Kuwano, Mayumi Ono

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Expression of N-myc downstream-regulated gene 1 (NDRG1) is significantly correlated with tumor angiogenesis by human gastric cancer. Results: NDRG1 overexpression induced JNK activation and expression of IL-1α and angiogenic CXC chemokines accompanied by tumor angiogenesis. Conclusion: NDRG1 promoted IL-1α-induced tumor angiogenesis through JNK/AP-1 activation. Significance: NDRG1/JNK/IL-1 axis could be a useful target for development of a novel anti-angiogenic strategy in gastric cancer.

Original languageEnglish
Pages (from-to)25025-25037
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
Publication statusPublished - Aug 30 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Murakami, Y., Watari, K., Shibata, T., Uba, M., Ureshino, H., Kawahara, A., Abe, H., Izumi, H., Mukaida, N., Kuwano, M., & Ono, M. (2013). N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells. Journal of Biological Chemistry, 288(35), 25025-25037. https://doi.org/10.1074/jbc.M113.472068