N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin

Yoo Hyun Song, Yoshinao Oda, Mikifumi Hori, Kentaro Kuroiwa, Mayumi Ono, Fumihito Hosoi, Yuji Basaki, Shoji Tokunaga, Michihiko Kuwano, Seiji Naito, Masazumi Tsuneyoshi

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Abstract

N-myc downstream regulated gene-1 (NDRG1)/Cap43 plays an important role in tumor progression and metastases in many kinds of cancers. Recently, it was reported that NDRG1/Cap43 is involved in the aggressiveness of prostate cancer and also that its expression is associated with the expression of E-cadherin in prostate carcinoma cell lines. In the current study, to elucidate the functional and pathologic roles of NDRG1/Cap43 in prostate cancer, we investigated whether the expression of NDRG1/Cap43 is associated with the clinicopathologic parameters of prostate cancer or E-cadherin expression. NDRG1/Cap43 expression and E-cadherin expression were examined immunohistochemically in 148 patients with prostate cancer. We investigated the correlation between membranous or cytoplasmic expression of NDRG1/Cap43 and E-cadherin and evaluated the prognostic or clinicopathologic significance of the expression of NDRG1/Cap43. The patients with decreased NDRG1/Cap43 membranous expression showed significantly lower disease-free survival rates compared with the patients with preserved NDRG1/Cap43 membranous expression. Decreased membranous and high cytoplasmic NDRG1/Cap43 expression was also correlated with a higher Gleason score. A significant correlation was observed between NDRG1/Cap43 membranous expression and E-cadherin membranous expression (r = 0.7130; P < .0001) and between NDRG1/Cap43 cytoplasmic expression and E-cadherin cytoplasmic expression (r = 0.5847; P < .0001). Decreased NDRG1/Cap43 membranous expression had a significant impact on patient disease-free survival in multivariate analysis (P = .0175). NDRG1/Cap43 could be a novel marker for malignant progression and poor prognosis in prostate cancer, plausibly in its close association with the down-regulation of E-cadherin expression.

Original languageEnglish
Pages (from-to)214-222
Number of pages9
JournalHuman Pathology
Volume41
Issue number2
DOIs
Publication statusPublished - Feb 1 2010

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Cadherins
Prostatic Neoplasms
Genes
Disease-Free Survival
Neoplasm Grading
Prostate
Neoplasms
Down-Regulation
Multivariate Analysis
Survival Rate

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin. / Song, Yoo Hyun; Oda, Yoshinao; Hori, Mikifumi; Kuroiwa, Kentaro; Ono, Mayumi; Hosoi, Fumihito; Basaki, Yuji; Tokunaga, Shoji; Kuwano, Michihiko; Naito, Seiji; Tsuneyoshi, Masazumi.

In: Human Pathology, Vol. 41, No. 2, 01.02.2010, p. 214-222.

Research output: Contribution to journalArticle

Song, YH, Oda, Y, Hori, M, Kuroiwa, K, Ono, M, Hosoi, F, Basaki, Y, Tokunaga, S, Kuwano, M, Naito, S & Tsuneyoshi, M 2010, 'N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin', Human Pathology, vol. 41, no. 2, pp. 214-222. https://doi.org/10.1016/j.humpath.2009.07.011
Song, Yoo Hyun ; Oda, Yoshinao ; Hori, Mikifumi ; Kuroiwa, Kentaro ; Ono, Mayumi ; Hosoi, Fumihito ; Basaki, Yuji ; Tokunaga, Shoji ; Kuwano, Michihiko ; Naito, Seiji ; Tsuneyoshi, Masazumi. / N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin. In: Human Pathology. 2010 ; Vol. 41, No. 2. pp. 214-222.
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