NADPH oxidase-related pathophysiology in experimental models of stroke

Hiroshi Yao, Tetsuro Ago, Takanari Kitazono, Toru Nabika

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Several experimental studies have indicated that nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) exert detrimental effects on ischemic brain tissue; Nox-knockout mice generally exhibit resistance to damage due to experimental stroke following middle cerebral artery occlusion (MCAO). Furthermore, our previous MCAO study indicated that infarct size and blood-brain barrier breakdown are enhanced in mice with pericyte-specific overexpression of Nox4, relative to levels observed in controls. However, it remains unclear whether Nox affects the stroke outcome directly by increasing oxidative stress at the site of ischemia, or indirectly by modifying physiological variables such as blood pressure or cerebral blood flow (CBF). Because of technical problems in the measurement of physiological variables and CBF, it is often difficult to address this issue in mouse models due to their small body size; in our previous study, we examined the effects of Nox activity on focal ischemic injury in a novel congenic rat strain: stroke-prone spontaneously hypertensive rats with loss-of-function in Nox. In this review, we summarize the current literature regarding the role of Nox in focal ischemic injury and discuss critical issues that should be considered when investigating Nox-related pathophysiology in animal models of stroke.

Original languageEnglish
Article number2123
JournalInternational journal of molecular sciences
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 11 2017

Fingerprint

nicotinamide
NADPH Oxidase
oxidase
adenines
strokes
NADP
phosphates
Oxidoreductases
Phosphates
Theoretical Models
Stroke
Cerebrovascular Circulation
Middle Cerebral Artery Infarction
occlusion
blood flow
arteries
Rats
Blood
rats
mice

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

NADPH oxidase-related pathophysiology in experimental models of stroke. / Yao, Hiroshi; Ago, Tetsuro; Kitazono, Takanari; Nabika, Toru.

In: International journal of molecular sciences, Vol. 18, No. 10, 2123, 11.10.2017.

Research output: Contribution to journalReview article

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