NAlkylation of tosylamides using esters as primary and tertiary alkyl sources: Mediated by hydrosilanes activated by a ruthenium catalyst

Takashi Nishikata, Hideo Nagashima

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Select your group: Either a primary or tertiary alkyl group can be selectively introduced onto the nitrogen atom of tosylamides in a ruthenium-catalyzed reaction employing hydrosilanes through a judicious choice in the esters that serve as the alkyl source (see scheme; Ts= 4-toluenesulfonyl). These N-alkylation reactions are useful for construction of naturally occurring azacyclic skeletons.

Original languageEnglish
Pages (from-to)5363-5366
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number22
DOIs
Publication statusPublished - May 29 2012

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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