Nano-scale design of novel stationary phases to enhance selectivity for molecular shape and size in liquid chromatography

Kiyokatsu Jinno, Kazuyo Nakagawa, Yoshihiro Saito, Hatsuichi Ohta, Hideo Nagashima, Kenji Itoh, Jim Archer, Yung Lin Chen

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The design of novel stationary phases in liquid chromatography (LC) which offer enhanced selectivity or better resolution of fullerenes is described. Fullerene molecules have been chosen due to their recent popularity and importance in both chemistry and the materials science fields. From the previous studies on octadecyl modified silica (ODS) stationary phases in LC an important structural requirement for stationary phases that can effectively separate fullerenes has been identified. The distance between each bonded functional group on the silica surface that is best-fit to the fullerene diameter (e.g. C60 has ca. 7 Å diameter and inter-ligand distance 7.1 Å of ODS phase is the best-fit size) is the key to improve the separation performance. A phenyl ligand contribution to fullerenes retention has also been found to be important. The size and shape of the cavity-like multilegged phenyl bonded phases is the dominant parameter for the structural recognition of fullerenes. By utilizing these factors a novel stationary phase structure is proposed.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalJournal of Chromatography A
Volume691
Issue number1-2
DOIs
Publication statusPublished - Feb 3 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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