Nanobiodevice-based Single Biomolecule Analysis, Single-Cell Analysis, and <i>in vivo</i> Imaging for Cancer Diagnosis, Cancer Theranostics, and iPS Cell-based Regenerative Medicine

Noritada Kaji, Yoshinobu Baba

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Numerous nanobiodevices have been developed for cancer diagnosis through the analysis of cancer cells and cancer-related biomolecules, cancer gene therapy, and iPS cell-based regenerative medicine. A microchamber array, which is fabricated on a plastic chip, enables to develop a reliable circulating tumor cell (CTC) detection technique for cancer metastasis diagnosis. A nanopillar-array or a nanowire-array on a quartz chip allows ultrafast analysis of DNA and microRNA within 1 s for the molecular diagnosis of cancer. Immunopillar devices, which contain a tremendous amount of antibody-immobilized microparticles inside an immunopillar structure, have realized fast and low invasive “from blood to analysis” type biomarker detection of cancer with a pM detection sensitivity within 5 min. Quantum dots and gene delivery nanodevices are applied to single cancer cell diagnosis, <i>in vivo</i> imaging for iPS cell based regenerative medicine, and theranostic devices for cancer diagnosis and therapy.
    Original languageEnglish
    Pages (from-to)859-864
    Number of pages6
    Journalanalytical sciences
    Volume30
    Issue number9
    DOIs
    Publication statusPublished - 2014

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