Nanobiodevices for biomolecule analysis and imaging

Takao Yasui, Noritada Kaji, Yoshinobu Baba

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Nanobiodevices have been developed to analyze biomolecules and cells for biomedical applications. In this review, we discuss several nanobiodevices used for disease-diagnostic devices, molecular imaging devices, regenerative medicine, and drug-delivery systems and describe the numerous advantages of nanobiodevices, especially in biological, medical, and clinical applications. This review also outlines the fabrication technologies for nanostructures and nanomaterials, including top-down nanofabrication and bottom-up molecular self-assembly approaches. We describe nanopillar arrays and nanowall arrays for the ultrafast separation of DNA or protein molecules and nanoball materials for the fast separation of a wide range of DNA molecules, and we present examples of applications of functionalized carbon nanotubes to obtain information about subcellular localization on the basis of mobility differences between free fluorophores and fluorophore-labeled carbon nanotubes. Finally, we discuss applications of newly synthesized quantum dots to the screening of small interfering RNA, highly sensitive detection of disease-related proteins, and development of cancer therapeutics and diagnostics.

Original languageEnglish
Pages (from-to)83-96
Number of pages14
JournalAnnual Review of Analytical Chemistry
Volume6
DOIs
Publication statusPublished - Jun 1 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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