Nanodomains in a hydrophilic-hydrophobic IPN based on poly(2-hydroxyethyl acrylate) and poly(ethyl acrylate)

G. Gallego Ferrer, M. Salmerón Sánchez, J. L.Gómez Ribelles, F. J.Romero Colomer, M. Monleón Pradas

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The morphology of a series of hydrogels based on the interpenetration of poly(2-hydroxyethyl acrylate) and poly(ethyl acrylate) has been studied through transmission electron microscopy, TEM, atomic force microscopy, AFM, and dynamic-mechanical spectroscopy, DMA. For the TEM analysis phosphotungstic acid, PTA, was used as alternative selective staining agent to those commonly used. The good agreement between TEM and AFM images allowed us to confirm that the PTA technique is a very powerful tool for TEM analysis of these hydrogel systems. All the results show that the IPNs presented phase-separation with two kinds of microdomains: those preferentially with a hydrophilic nature and those with preferentially a hydrophobic one, of sizes that range from 30 nm to 100 nm. Each one of these domains is composed by smaller nanodomains of alternating hydrophobic and hydrophilic component ranging between 6 and 10 nm sizes, those preferentially with a hydrophilic nature having a larger proportion of hydrophilic nanodomains. The AFM images of the IPN with the highest PHEA mass fraction, xPHEA = 0.75, suggest that the hydrophilic phase is co-continuous in the material. A disperse hydrophilic phase is found when the PHEA mass fraction is reduced up to xPHEA = 0.38. This phase-separation is explained in terms of some characteristic parameters of the networks such as the mesh size and the number of units between cross-links. The morphology found makes the systems very attractive for cell adhesion substrates and for matrices of scaffolds in soft tissue engineering.

Original languageEnglish
Pages (from-to)3136-3145
Number of pages10
JournalEuropean Polymer Journal
Volume43
Issue number8
DOIs
Publication statusPublished - Aug 1 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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