Nanoparticles of Adaptive Supramolecular Networks Self-Assembled from Nucleotides and Lanthanide Ions

Ryuhei Nishiyabu, Nozomi Hashimoto, Ten Cho, Kazuto Watanabe, Takefumi Yasunaga, Ayataka Endo, Kenji Kaneko, Takuro Niidome, Masaharu Murata, Chihaya Adachi, Yoshiki Katayama, Makoto Hashizume, Nobuo Kimizuka

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

Amorphous nanoparticles of supramolecular coordination polymer networks are spontaneously self-assembled from nucleotides and lanthanide ions in water. They show intrinsic functions such as energy transfer from nucleobase to lanthanide ions and excellent performance as contrast enhancing agents for magnetic resonance imaging(MRI). Furthermore, adaptive inclusion properties are observed in the self- assembly process: functional materials such as fluorescent dyes, metal nanoparticles, and proteins are facilely encapsulated. Dyes in these nanoparticles fluoresce in high quantum yields with a single exponential decay, indicating that guest molecules are monomerically wrapped in the network. Gold nanoparticles and ferritin were also wrapped by the supramolecular shells. In addition, these nucleotide/lanthanide nanoparticles also serve as scaffolds for immobilizing enzymes. The adaptive nature of present supramolecular nanoparticles provides a versatile platform that can be utilized in a variety of applications ranging from material to biomedical sciences. As examples, biocompatibility and liver-directing characteristics in in vivo tissue localization experiments are demonstrated.

Original languageEnglish
Pages (from-to)2151-2158
Number of pages8
JournalJournal of the American Chemical Society
Volume131
Issue number6
DOIs
Publication statusPublished - Feb 18 2009

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Lanthanoid Series Elements
Nucleotides
Rare earth elements
Nanoparticles
Ions
Dyes
Metal Nanoparticles
Functional materials
Metal nanoparticles
Energy Transfer
Quantum yield
Magnetic resonance
Scaffolds (biology)
Ferritins
Biocompatibility
Fluorescent Dyes
Scaffolds
Gold
Liver
Energy transfer

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Nanoparticles of Adaptive Supramolecular Networks Self-Assembled from Nucleotides and Lanthanide Ions. / Nishiyabu, Ryuhei; Hashimoto, Nozomi; Cho, Ten; Watanabe, Kazuto; Yasunaga, Takefumi; Endo, Ayataka; Kaneko, Kenji; Niidome, Takuro; Murata, Masaharu; Adachi, Chihaya; Katayama, Yoshiki; Hashizume, Makoto; Kimizuka, Nobuo.

In: Journal of the American Chemical Society, Vol. 131, No. 6, 18.02.2009, p. 2151-2158.

Research output: Contribution to journalArticle

Nishiyabu, R, Hashimoto, N, Cho, T, Watanabe, K, Yasunaga, T, Endo, A, Kaneko, K, Niidome, T, Murata, M, Adachi, C, Katayama, Y, Hashizume, M & Kimizuka, N 2009, 'Nanoparticles of Adaptive Supramolecular Networks Self-Assembled from Nucleotides and Lanthanide Ions', Journal of the American Chemical Society, vol. 131, no. 6, pp. 2151-2158. https://doi.org/10.1021/ja8058843
Nishiyabu, Ryuhei ; Hashimoto, Nozomi ; Cho, Ten ; Watanabe, Kazuto ; Yasunaga, Takefumi ; Endo, Ayataka ; Kaneko, Kenji ; Niidome, Takuro ; Murata, Masaharu ; Adachi, Chihaya ; Katayama, Yoshiki ; Hashizume, Makoto ; Kimizuka, Nobuo. / Nanoparticles of Adaptive Supramolecular Networks Self-Assembled from Nucleotides and Lanthanide Ions. In: Journal of the American Chemical Society. 2009 ; Vol. 131, No. 6. pp. 2151-2158.
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