Nanopillars, Nanowires and Nanoballs for DNA and Protein Analysis

Noritada Kaji, Takao Yasui, Manabu Tokeshi, Yoshinobu Baba

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent development of nanofluidic devices using nanopillars, nanowires, and nanoballs for high-performance biomolecules analysis are reviewed in this chapter. Two approaches, "top-down" fabrication techniques and "bottom-up" self-assemble techniques, were applied to construct nanospace inside microchannels, and various biomolecules including DNA, RNA and proteins were successfully separated within a few seconds. These separation techniques enabled high throughput analysis that had never achieved by natural or synthetic polymers and explored a new bioanalytical field based on molecular dynamics in nanospace. Hybrid use of the both approaches might be promising for future home diagnostic devices and clinical applications.

Original languageEnglish
Title of host publicationNanofluidics, 2nd Edition
EditorsAleksandar Ivanov, Joshua Edel, Paul O'Brien, MinJun Kim
PublisherRoyal Society of Chemistry
Pages76-98
Number of pages23
Edition41
DOIs
Publication statusPublished - Jan 1 2017

Publication series

NameRSC Nanoscience and Nanotechnology
Number41
Volume2017-January
ISSN (Print)1757-7136
ISSN (Electronic)1757-7144

Fingerprint

Biomolecules
Nanowires
DNA
nanowires
deoxyribonucleic acid
Nanofluidics
proteins
Proteins
microchannels
Microchannels
RNA
Molecular dynamics
Polymers
Throughput
molecular dynamics
Fabrication
fabrication
polymers

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Atomic and Molecular Physics, and Optics
  • Materials Science(all)
  • Engineering(all)

Cite this

Kaji, N., Yasui, T., Tokeshi, M., & Baba, Y. (2017). Nanopillars, Nanowires and Nanoballs for DNA and Protein Analysis. In A. Ivanov, J. Edel, P. O'Brien, & M. Kim (Eds.), Nanofluidics, 2nd Edition (41 ed., pp. 76-98). (RSC Nanoscience and Nanotechnology; Vol. 2017-January, No. 41). Royal Society of Chemistry. https://doi.org/10.1039/9781849735230-00076

Nanopillars, Nanowires and Nanoballs for DNA and Protein Analysis. / Kaji, Noritada; Yasui, Takao; Tokeshi, Manabu; Baba, Yoshinobu.

Nanofluidics, 2nd Edition. ed. / Aleksandar Ivanov; Joshua Edel; Paul O'Brien; MinJun Kim. 41. ed. Royal Society of Chemistry, 2017. p. 76-98 (RSC Nanoscience and Nanotechnology; Vol. 2017-January, No. 41).

Research output: Chapter in Book/Report/Conference proceedingChapter

Kaji, N, Yasui, T, Tokeshi, M & Baba, Y 2017, Nanopillars, Nanowires and Nanoballs for DNA and Protein Analysis. in A Ivanov, J Edel, P O'Brien & M Kim (eds), Nanofluidics, 2nd Edition. 41 edn, RSC Nanoscience and Nanotechnology, no. 41, vol. 2017-January, Royal Society of Chemistry, pp. 76-98. https://doi.org/10.1039/9781849735230-00076
Kaji N, Yasui T, Tokeshi M, Baba Y. Nanopillars, Nanowires and Nanoballs for DNA and Protein Analysis. In Ivanov A, Edel J, O'Brien P, Kim M, editors, Nanofluidics, 2nd Edition. 41 ed. Royal Society of Chemistry. 2017. p. 76-98. (RSC Nanoscience and Nanotechnology; 41). https://doi.org/10.1039/9781849735230-00076
Kaji, Noritada ; Yasui, Takao ; Tokeshi, Manabu ; Baba, Yoshinobu. / Nanopillars, Nanowires and Nanoballs for DNA and Protein Analysis. Nanofluidics, 2nd Edition. editor / Aleksandar Ivanov ; Joshua Edel ; Paul O'Brien ; MinJun Kim. 41. ed. Royal Society of Chemistry, 2017. pp. 76-98 (RSC Nanoscience and Nanotechnology; 41).
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