Nanostructures integrated with a nanochannel for slowing down DNA translocation velocity for nanopore sequencing

Xiaoyin Sun, Takao Yasui, Takeshi Yanagida, Noritada Kaji, Sakon Rahong, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Here, we developed a device integrated with a nanochannel and nanostructures to slow DNA translocation velocity. We found that translocation velocity of a single DNA molecule inside a nanochannel was decreased by pre-elongating it using some nanostructures, such as a shallow channel or nanopillars. This decrease of the translocation velocity was associated with the DNA mobility change, which is an intrinsic parameter of DNA molecules and unaffected by an electric field.

Original languageEnglish
Pages (from-to)735-738
Number of pages4
Journalanalytical sciences
Volume33
Issue number6
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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