Nanowall array chips for DNA separation

Takao Yasui, Noritada Kaji, Ryo Ogawa, Shingi Hashioka, Manabu Tokeshi, Yasuhiro Horiike, Yoshinobu Baba

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A 25 s separation of DNA fragments (48.5 and 1 kbp fragments) was achieved by a nanowall array structure, although the separation of 1 kbp and 100 bp DNA fragments was not. Direct observation of a single DNA molecule indicates that it takes over 20 s for an elongated DNA molecule to relax inside the nanowall array structure. Numerical fitting of DNA molecular dynamics reveals that the balance between times for the transverse of an elongated DNA molecule and the relaxation process of a DNA molecule inside the nanowall array structure governs the separation of DNA.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages638-640
Number of pages3
Publication statusPublished - 2011
Externally publishedYes
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume1

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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  • Cite this

    Yasui, T., Kaji, N., Ogawa, R., Hashioka, S., Tokeshi, M., Horiike, Y., & Baba, Y. (2011). Nanowall array chips for DNA separation. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 638-640). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).