Na+-dependent fructose transport via rNaGLT1 in rat kidney

Naoshi Horiba, Satohiro Masuda, Chiharu Ohnishi, Daisuke Takeuchi, Masahiro Okuda, Ken Ichi Inui

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We found a system of Na+-dependent uptake of fructose by rat renal brush-border membrane vesicles. It consisted of two saturable components, and was thought to involve at least two transporters. rNaGLT1, a novel glucose transporter in rat kidney, showed fructose uptake as well as α-methyl-D-glucopyranoside uptake by transfected HEK293 cells. The features of the lower affinity type of fructose transporter in the brush-border membranes, such as affinity and substrate recognition, were very comparable with those of rNaGLT1-transfected HEK293 cells. These results indicated that rNaGLT1 is a primary fructose transporter in rat renal brush-border membranes.

Original languageEnglish
Pages (from-to)276-280
Number of pages5
JournalFEBS Letters
Volume546
Issue number2-3
DOIs
Publication statusPublished - Jul 10 2003

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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