Nationwide epidemiological survey of early chronic pancreatitis in Japan

Research Committee of Intractable Pancreatic Diseases in Japan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: The world’s first diagnostic criteria for early CP were proposed in 2009 in Japan. This study aimed to clarify the clinico-epidemiological features of early CP in Japan. Methods: Patients with early CP who were diagnosed according to the diagnostic criteria for early CP and had visited the selected hospitals in 2011 were surveyed. The study consisted of two-stage surveys: the number of patients with early CP was estimated by the first questionnaire and their clinical features were assessed by the second questionnaire. Results: The estimated number of early CP patients was 5410 (95% confidence interval 3675–6945), with an overall prevalence of 4.2 per 100,000 persons. The number of patients who were newly diagnosed with early CP was estimated to be 1330 (95% confidence interval 1058–1602), with an annual incidence of 1.0 per 100,000 persons. Detailed clinical information was obtained in 151 patients in the second survey. The male-to-female sex ratio was 1.32:1. The mean age was 60.4 and the mean age at disease onset was 55.4. Idiopathic (47.7%) and alcoholic (45.0%) were the two most common etiologies. Proportions of female and idiopathic cases were higher in early CP than in definite CP. Hyperechoic foci without shadowing and stranding were the most common findings on endoscopic ultrasonography. The clinical profiles of early CP patients who showed lobularity with honeycombing on endoscopic ultrasonography or previous episodes of acute pancreatitis were similar to those of definite CP patients. Conclusions: We clarified the current status of early CP in Japan.

Original languageEnglish
Pages (from-to)992-1000
Number of pages9
JournalJournal of gastroenterology
Volume52
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

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Chronic Pancreatitis
Japan
Endosonography
Confidence Intervals
Sex Ratio
Surveys and Questionnaires
Age of Onset
Pancreatitis
Incidence

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Nationwide epidemiological survey of early chronic pancreatitis in Japan. / Research Committee of Intractable Pancreatic Diseases in Japan.

In: Journal of gastroenterology, Vol. 52, No. 8, 01.08.2017, p. 992-1000.

Research output: Contribution to journalArticle

Research Committee of Intractable Pancreatic Diseases in Japan 2017, 'Nationwide epidemiological survey of early chronic pancreatitis in Japan', Journal of gastroenterology, vol. 52, no. 8, pp. 992-1000. https://doi.org/10.1007/s00535-017-1311-8
Research Committee of Intractable Pancreatic Diseases in Japan. Nationwide epidemiological survey of early chronic pancreatitis in Japan. Journal of gastroenterology. 2017 Aug 1;52(8):992-1000. https://doi.org/10.1007/s00535-017-1311-8
Research Committee of Intractable Pancreatic Diseases in Japan. / Nationwide epidemiological survey of early chronic pancreatitis in Japan. In: Journal of gastroenterology. 2017 ; Vol. 52, No. 8. pp. 992-1000.
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title = "Nationwide epidemiological survey of early chronic pancreatitis in Japan",
abstract = "Background: The world’s first diagnostic criteria for early CP were proposed in 2009 in Japan. This study aimed to clarify the clinico-epidemiological features of early CP in Japan. Methods: Patients with early CP who were diagnosed according to the diagnostic criteria for early CP and had visited the selected hospitals in 2011 were surveyed. The study consisted of two-stage surveys: the number of patients with early CP was estimated by the first questionnaire and their clinical features were assessed by the second questionnaire. Results: The estimated number of early CP patients was 5410 (95{\%} confidence interval 3675–6945), with an overall prevalence of 4.2 per 100,000 persons. The number of patients who were newly diagnosed with early CP was estimated to be 1330 (95{\%} confidence interval 1058–1602), with an annual incidence of 1.0 per 100,000 persons. Detailed clinical information was obtained in 151 patients in the second survey. The male-to-female sex ratio was 1.32:1. The mean age was 60.4 and the mean age at disease onset was 55.4. Idiopathic (47.7{\%}) and alcoholic (45.0{\%}) were the two most common etiologies. Proportions of female and idiopathic cases were higher in early CP than in definite CP. Hyperechoic foci without shadowing and stranding were the most common findings on endoscopic ultrasonography. The clinical profiles of early CP patients who showed lobularity with honeycombing on endoscopic ultrasonography or previous episodes of acute pancreatitis were similar to those of definite CP patients. Conclusions: We clarified the current status of early CP in Japan.",
author = "{Research Committee of Intractable Pancreatic Diseases in Japan} and Atsushi Masamune and Kazuhiro Kikuta and Tatsuhide Nabeshima and Eriko Nakano and Morihisa Hirota and Atsushi Kanno and Kiyoshi Kume and Shin Hamada and Tetsuhide Ito and Motokazu Fujita and Atsushi Irisawa and Masanori Nakashima and Keiji Hanada and Takaaki Eguchi and Ryusuke Kato and Osamu Inatomi and Akio Shirane and Yoshifumi Takeyama and Ichiro Tsuji and Tooru Shimosegawa",
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T1 - Nationwide epidemiological survey of early chronic pancreatitis in Japan

AU - Research Committee of Intractable Pancreatic Diseases in Japan

AU - Masamune, Atsushi

AU - Kikuta, Kazuhiro

AU - Nabeshima, Tatsuhide

AU - Nakano, Eriko

AU - Hirota, Morihisa

AU - Kanno, Atsushi

AU - Kume, Kiyoshi

AU - Hamada, Shin

AU - Ito, Tetsuhide

AU - Fujita, Motokazu

AU - Irisawa, Atsushi

AU - Nakashima, Masanori

AU - Hanada, Keiji

AU - Eguchi, Takaaki

AU - Kato, Ryusuke

AU - Inatomi, Osamu

AU - Shirane, Akio

AU - Takeyama, Yoshifumi

AU - Tsuji, Ichiro

AU - Shimosegawa, Tooru

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background: The world’s first diagnostic criteria for early CP were proposed in 2009 in Japan. This study aimed to clarify the clinico-epidemiological features of early CP in Japan. Methods: Patients with early CP who were diagnosed according to the diagnostic criteria for early CP and had visited the selected hospitals in 2011 were surveyed. The study consisted of two-stage surveys: the number of patients with early CP was estimated by the first questionnaire and their clinical features were assessed by the second questionnaire. Results: The estimated number of early CP patients was 5410 (95% confidence interval 3675–6945), with an overall prevalence of 4.2 per 100,000 persons. The number of patients who were newly diagnosed with early CP was estimated to be 1330 (95% confidence interval 1058–1602), with an annual incidence of 1.0 per 100,000 persons. Detailed clinical information was obtained in 151 patients in the second survey. The male-to-female sex ratio was 1.32:1. The mean age was 60.4 and the mean age at disease onset was 55.4. Idiopathic (47.7%) and alcoholic (45.0%) were the two most common etiologies. Proportions of female and idiopathic cases were higher in early CP than in definite CP. Hyperechoic foci without shadowing and stranding were the most common findings on endoscopic ultrasonography. The clinical profiles of early CP patients who showed lobularity with honeycombing on endoscopic ultrasonography or previous episodes of acute pancreatitis were similar to those of definite CP patients. Conclusions: We clarified the current status of early CP in Japan.

AB - Background: The world’s first diagnostic criteria for early CP were proposed in 2009 in Japan. This study aimed to clarify the clinico-epidemiological features of early CP in Japan. Methods: Patients with early CP who were diagnosed according to the diagnostic criteria for early CP and had visited the selected hospitals in 2011 were surveyed. The study consisted of two-stage surveys: the number of patients with early CP was estimated by the first questionnaire and their clinical features were assessed by the second questionnaire. Results: The estimated number of early CP patients was 5410 (95% confidence interval 3675–6945), with an overall prevalence of 4.2 per 100,000 persons. The number of patients who were newly diagnosed with early CP was estimated to be 1330 (95% confidence interval 1058–1602), with an annual incidence of 1.0 per 100,000 persons. Detailed clinical information was obtained in 151 patients in the second survey. The male-to-female sex ratio was 1.32:1. The mean age was 60.4 and the mean age at disease onset was 55.4. Idiopathic (47.7%) and alcoholic (45.0%) were the two most common etiologies. Proportions of female and idiopathic cases were higher in early CP than in definite CP. Hyperechoic foci without shadowing and stranding were the most common findings on endoscopic ultrasonography. The clinical profiles of early CP patients who showed lobularity with honeycombing on endoscopic ultrasonography or previous episodes of acute pancreatitis were similar to those of definite CP patients. Conclusions: We clarified the current status of early CP in Japan.

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