Nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan

Ryoichi Hamasuna, Mitsuru Yasuda, Kiyohito Ishikawa, Shinya Uehara, Satoshi Takahashi, Hiroshi Hayami, Shingo Yamamoto, Tetsuro Matsumoto, Shinichi Minamitani, Akira Watanabe, Aikichi Iwamoto, Kyoichi Totsuka, Junichi Kadota, Keisuke Sunakawa, Junko Sato, Hideaki Hanaki, Taiji Tsukamoto, Hiroshi Kiyota, Shin Egawa, Kazushi TanakaSoichi Arakawa, Masato Fujisawa, Hiromi Kumon, Kanao Kobayashi, Akio Matsubara, Seiji Naito, Katsunori Tatsugami, Shin Ito, Harunori Narita, Mototsugu Kanokogi, Toru Sumii, Kenji Ito, Takahide Hosobe, Shuichi Kawai, Hiromi Kawano, Kazuo Takayama, Takamasa Yamaguchi, Katsuhisa Endo, Takamine Yamauchi, Shinichi Maeda, Mutsumasa Yoh, Masanobu Horie, Masayasu Ito, Hirofumi Chokyu, Hideari Ihara, Kikuo Akiyama, Satoshi Uno, Koichi Monden, Shinichi Kaji, Hirofumi Nishimura, Motoshi Kawahara, Takashi Sato, Takatoshi Konishi, Shohei Nishi, Satoshi Ishihara, Masaru Yoshioka

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Abstract

Neisseria gonorrhoeae is one of the most important pathogens causing sexually transmitted infection, and strains that are resistant to several antimicrobials are increasing. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the first nationwide surveillance. The urethral discharge was collected from male patients with urethritis at 51 medical facilities from April 2009 to October 2010. Of the 156 specimens, 83 N. gonorrhoeae strains were tested for susceptibility to 18 antimicrobial agents. The prevalence of β-lactamase-producing strains and chromosomally mediated resistant strains were 7.2 % and 16.5 %, respectively. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) of ceftriaxone for 7 strains (8.4 %) was 0.125 μg/ml. One strain was resistant to cefixime (MIC 0.5 μg/ml). The MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin, and tosufloxacin, showed a bimodal distribution. The MIC of sitafloxacin was lower than those of the three fluoroquinolones listed here, and it was found that the antimicrobial activity of sitafloxacin was stronger than that of the fluoroquinolones. The MIC of azithromycin in 2 strains was 2 μg/ml, but no high-level resistance to macrolides was detected.

Original languageEnglish
Pages (from-to)571-578
Number of pages8
JournalJournal of Infection and Chemotherapy
Volume19
Issue number4
DOIs
Publication statusPublished - Aug 2013

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All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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