Natural history of branch duct intraductal papillary mucinous neoplasms of the pancreas: A multicenter study in Japan

Hiroyuki Maguchi, Satoshi Tanno, Nobumasa Mizuno, Keiji Hanada, Go Kobayashi, Takashi Hatori, Yoshihiko Sadakari, Taketo Yamaguchi, Kosuke Tobita, Ryuichiro Doi, Akio Yanagisawa, Masao Tanaka

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

OBJECTIVE: The aim of this study was to evaluate the long-term follow-up results of patients with branch duct intraductal papillary mucinous neoplasms (BD-IPMNs) without mural nodules (MNs) at 10 representative institutions in Japan. METHODS: We analyzed 349 follow-up BD-IPMN patients who had no MNs on endoscopic ultrasonography at initial diagnosis. RESULTS: Observation periods ranged from 1 to 16.3 years (median, 3.7 years). Sixty-two (17.8%) patients exhibited disease progression during follow-up. Twenty-two underwent surgery, leading to a pathological diagnosis of carcinoma in 9 and adenoma in 13. Although the remaining 287 (82.2%) showed no changes, 7 underwent surgery because of symptoms (n = 2), choice (n = 2), or development of pancreatic ductal adenocarcinoma (n = 3); all of them were diagnosed pathologically as adenomas. Of the 29 patients undergoing surgery, all 9 with carcinoma exhibited signs of progression, such as increased main pancreatic duct diameter and/or appearance of MNs. Pancreatic ductal adenocarcinomas and additional BD-IPMNs developed in 7 (2.0%) and 13 (3.7%), respectively. Overall, 320 (91.7%) patients were followed without surgery. CONCLUSIONS: Most BD-IPMN patients who had no MNs on endoscopic ultrasonography could be managed without surgery. However, careful attention should be paid to disease progression and the development of pancreatic ductal adenocarcinomas during follow-up.

Original languageEnglish
Pages (from-to)364-370
Number of pages7
JournalPancreas
Volume40
Issue number3
DOIs
Publication statusPublished - Apr 1 2011

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Natural History
Pancreatic Neoplasms
Multicenter Studies
Japan
Endosonography
Adenocarcinoma
Adenoma
Disease Progression
Neoplasms
Carcinoma
Pancreatic Ducts
Observation

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Maguchi, H., Tanno, S., Mizuno, N., Hanada, K., Kobayashi, G., Hatori, T., ... Tanaka, M. (2011). Natural history of branch duct intraductal papillary mucinous neoplasms of the pancreas: A multicenter study in Japan. Pancreas, 40(3), 364-370. https://doi.org/10.1097/MPA.0b013e31820a5975

Natural history of branch duct intraductal papillary mucinous neoplasms of the pancreas : A multicenter study in Japan. / Maguchi, Hiroyuki; Tanno, Satoshi; Mizuno, Nobumasa; Hanada, Keiji; Kobayashi, Go; Hatori, Takashi; Sadakari, Yoshihiko; Yamaguchi, Taketo; Tobita, Kosuke; Doi, Ryuichiro; Yanagisawa, Akio; Tanaka, Masao.

In: Pancreas, Vol. 40, No. 3, 01.04.2011, p. 364-370.

Research output: Contribution to journalArticle

Maguchi, H, Tanno, S, Mizuno, N, Hanada, K, Kobayashi, G, Hatori, T, Sadakari, Y, Yamaguchi, T, Tobita, K, Doi, R, Yanagisawa, A & Tanaka, M 2011, 'Natural history of branch duct intraductal papillary mucinous neoplasms of the pancreas: A multicenter study in Japan', Pancreas, vol. 40, no. 3, pp. 364-370. https://doi.org/10.1097/MPA.0b013e31820a5975
Maguchi, Hiroyuki ; Tanno, Satoshi ; Mizuno, Nobumasa ; Hanada, Keiji ; Kobayashi, Go ; Hatori, Takashi ; Sadakari, Yoshihiko ; Yamaguchi, Taketo ; Tobita, Kosuke ; Doi, Ryuichiro ; Yanagisawa, Akio ; Tanaka, Masao. / Natural history of branch duct intraductal papillary mucinous neoplasms of the pancreas : A multicenter study in Japan. In: Pancreas. 2011 ; Vol. 40, No. 3. pp. 364-370.
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AU - Kobayashi, Go

AU - Hatori, Takashi

AU - Sadakari, Yoshihiko

AU - Yamaguchi, Taketo

AU - Tobita, Kosuke

AU - Doi, Ryuichiro

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AU - Tanaka, Masao

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