Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses

Shinya Tanaka, Takayuki Yoshimoto, Tetsuji Naka, Susumu Nakae, Yo Ichi Iwakura, Daniel Cua, Masato Kubo

Research output: Contribution to journalArticle

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Abstract

Effector Th17 cells are a major source of IL-17, a critical inflammatory cytokine in autoimmune diseases and in host defenses during bacterial infections. Recently, splenic lymphoid tissue inducer-like cells have been reported to be a source of T cell independent IL-17. In this study, we report that the immune system contains a unique set of natural occurring IL-17 producing cell, "natural" Th17 (nTh17), which are a memory-like T cell subset. The nTh17 cells can develop in the absence of the IL-6/STAT3 signaling axis required by inducible Th17 cells. The nTh17 cell population is distinct from conventional inducible Th17 cells, since nTh17 cells express substantial amounts of IL-17A (IL-17), but not IL-17F, under the control of the master regulator, RORγt. The nTh17 cells simultaneously produce IFN-γ. DO11.10 transgenic mice with a Rag-/- background (DO11.10 Rag -/-) lack nTh17 cells, and, following intranasal administration of OVA, IL-17-dependent neutrophil infiltration occurs in DO11.10 transgenic mice, but not in DO11.10 Rag-/- mice. The impaired neutrophil-dependent airway response is restored by adaptive transfer of nTh17 cells into DO11.10 Rag-/- mice. These results demonstrate that a novel T cell subset, nTh17, facilitates the early phase of Ag-induced airway responses and host defenses against pathogen invasion before the establishment of acquired immunity.

Original languageEnglish
Pages (from-to)7523-7530
Number of pages8
JournalJournal of Immunology
Volume183
Issue number11
DOIs
Publication statusPublished - Dec 1 2009
Externally publishedYes

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Th17 Cells
Interleukin-17
Neutrophils
T-Lymphocytes
T-Lymphocyte Subsets
Transgenic Mice
Intranasal Administration
Neutrophil Infiltration
Adaptive Immunity
Lymphoid Tissue
Helper-Inducer T-Lymphocytes
Bacterial Infections
Autoimmune Diseases
Immune System
Interleukin-6
Cytokines

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses. / Tanaka, Shinya; Yoshimoto, Takayuki; Naka, Tetsuji; Nakae, Susumu; Iwakura, Yo Ichi; Cua, Daniel; Kubo, Masato.

In: Journal of Immunology, Vol. 183, No. 11, 01.12.2009, p. 7523-7530.

Research output: Contribution to journalArticle

Tanaka, Shinya ; Yoshimoto, Takayuki ; Naka, Tetsuji ; Nakae, Susumu ; Iwakura, Yo Ichi ; Cua, Daniel ; Kubo, Masato. / Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses. In: Journal of Immunology. 2009 ; Vol. 183, No. 11. pp. 7523-7530.
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