Nectrianolins A, B, and C, new metabolites produced by endophytic fungus Nectria pseudotrichia 120-1NP

Nanang Rudianto Ariefta, Priska Kristiana, Handojo Hadi Nurjanto, Hiroyuki Momma, Eunsang Kwon, Tatsuya Ashitani, Keitaro Tawaraya, Tetsuya Murayama, Takuya Koseki, Hiroshi Furuno, Narandulam Usukhbayar, Ken ichi Kimura, Yoshihito Shiono

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Two sesquiterpene-epoxycyclohexenone conjugates, nectrianolins A (1) and B (2), together with a sesquiterpene, nectrianolin C (3), were isolated from the brown rice culture of Nectria pseudotrichia 120-1NP, an endophytic fungus isolated from Gliricidia sepium. Their structures were determined on the basis of 1D-/2D-NMR spectroscopy and HRESIMS data analyses in combination with chemical means. Nectrianolins A–C (1–3) exhibited cytotoxic activity against both HL60 and HeLa cells.

    Original languageEnglish
    Pages (from-to)4082-4086
    Number of pages5
    JournalTetrahedron Letters
    Volume58
    Issue number43
    DOIs
    Publication statusPublished - 2017

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

    Fingerprint

    Dive into the research topics of 'Nectrianolins A, B, and C, new metabolites produced by endophytic fungus Nectria pseudotrichia 120-1NP'. Together they form a unique fingerprint.

    Cite this