Negative regulation of cytokine signaling and immune responses by SOCS proteins

Akihiko Yoshimura, Hitomi Nishinakamura, Yumiko Matsumura, Toshikatsu Hanada

    Research output: Contribution to journalReview articlepeer-review

    116 Citations (Scopus)

    Abstract

    Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.

    Original languageEnglish
    Pages (from-to)100-110
    Number of pages11
    JournalArthritis Research and Therapy
    Volume7
    Issue number3
    DOIs
    Publication statusPublished - Jun 2005

    All Science Journal Classification (ASJC) codes

    • Rheumatology
    • Immunology and Allergy
    • Immunology

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