Abstract
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.
| Original language | English |
|---|---|
| Pages (from-to) | 100-110 |
| Number of pages | 11 |
| Journal | Arthritis Research and Therapy |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 1 2005 |
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All Science Journal Classification (ASJC) codes
- Rheumatology
- Immunology and Allergy
- Immunology
Cite this
Negative regulation of cytokine signaling and immune responses by SOCS proteins. / Yoshimura, Akihiko; Nishinakamura, Hitomi; Matsumura, Yumiko; Hanada, Toshikatsu.
In: Arthritis Research and Therapy, Vol. 7, No. 3, 01.06.2005, p. 100-110.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Negative regulation of cytokine signaling and immune responses by SOCS proteins
AU - Yoshimura, Akihiko
AU - Nishinakamura, Hitomi
AU - Matsumura, Yumiko
AU - Hanada, Toshikatsu
PY - 2005/6/1
Y1 - 2005/6/1
N2 - Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.
AB - Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.
UR - http://www.scopus.com/inward/record.url?scp=20144367654&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20144367654&partnerID=8YFLogxK
U2 - 10.1186/ar1741
DO - 10.1186/ar1741
M3 - Review article
C2 - 15899058
AN - SCOPUS:20144367654
VL - 7
SP - 100
EP - 110
JO - Arthritis Research and Therapy
JF - Arthritis Research and Therapy
SN - 1478-6354
IS - 3
ER -