Negative regulation of cytokine signaling and immune responses by SOCS proteins

Akihiko Yoshimura; Hitomi Nishinakamura; Yumiko Matsumura; Toshikatsu Hanada

doi:10.1186/ar1741

Negative regulation of cytokine signaling and immune responses by SOCS proteins

Akihiko Yoshimura, Hitomi Nishinakamura, Yumiko Matsumura, Toshikatsu Hanada

Research output: Contribution to journal › Review article › peer-review

116 Citations (Scopus)

Abstract

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.

Original language	English
Pages (from-to)	100-110
Number of pages	11
Journal	Arthritis Research and Therapy
Volume	7
Issue number	3
DOIs	https://doi.org/10.1186/ar1741
Publication status	Published - Jun 2005

All Science Journal Classification (ASJC) codes

Rheumatology
Immunology and Allergy
Immunology

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abstract = "Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.",

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AU - Yoshimura, Akihiko

AU - Nishinakamura, Hitomi

AU - Matsumura, Yumiko

AU - Hanada, Toshikatsu

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AB - Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.

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