Negative regulation of immediate-early gene expression of pseudorabies virus by interferon-

Noriko Tonomura, Etsuro Ono, Yukio Shimizu, Hiroshi Kida

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Pseudorabies virus (PrV) replication in Vero cells was suppressed by treatment with human natural interferon-α (IFN-α), Messenger RNA transcribed from the PrV immediate-early (IE) gene was reduced in the IFN-α-treated cells. Transient expression assays showed that transcription from the PrV IE promoter was selectively inhibited in the IFN-α-treated cells. Analysis of deletion mutants of the PrV IE promoter sequence suggested that at least one element between the transcription initiation site (+ 1) and -90 in the PrV IE promoter was concerned with the negative regulation.

Original languageEnglish
Pages (from-to)271-281
Number of pages11
JournalVeterinary Microbiology
Volume53
Issue number3-4
DOIs
Publication statusPublished - Dec 1 1996
Externally publishedYes

Fingerprint

Suid Herpesvirus 1
Immediate-Early Genes
Suid herpesvirus 1
interferons
Interferons
Gene Expression
gene expression
promoter regions
transcription (genetics)
Vero Cells
Transcription Initiation Site
cells
messenger RNA
Virus Replication
virus replication
mutants
Messenger RNA
assays
genes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • veterinary(all)

Cite this

Negative regulation of immediate-early gene expression of pseudorabies virus by interferon-. / Tonomura, Noriko; Ono, Etsuro; Shimizu, Yukio; Kida, Hiroshi.

In: Veterinary Microbiology, Vol. 53, No. 3-4, 01.12.1996, p. 271-281.

Research output: Contribution to journalArticle

Tonomura, Noriko ; Ono, Etsuro ; Shimizu, Yukio ; Kida, Hiroshi. / Negative regulation of immediate-early gene expression of pseudorabies virus by interferon-. In: Veterinary Microbiology. 1996 ; Vol. 53, No. 3-4. pp. 271-281.
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