Negative regulation of immediate-early gene expression of pseudorabies virus by interferon-

Noriko Tonomura, Etsuro Ono, Yukio Shimizu, Hiroshi Kida

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Pseudorabies virus (PrV) replication in Vero cells was suppressed by treatment with human natural interferon-α (IFN-α), Messenger RNA transcribed from the PrV immediate-early (IE) gene was reduced in the IFN-α-treated cells. Transient expression assays showed that transcription from the PrV IE promoter was selectively inhibited in the IFN-α-treated cells. Analysis of deletion mutants of the PrV IE promoter sequence suggested that at least one element between the transcription initiation site (+ 1) and -90 in the PrV IE promoter was concerned with the negative regulation.

Original languageEnglish
Pages (from-to)271-281
Number of pages11
JournalVeterinary Microbiology
Volume53
Issue number3-4
DOIs
Publication statusPublished - Dec 1 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • veterinary(all)

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