Neither MICA nor DEPDC5 genetic polymorphisms correlate with hepatocellular carcinoma recurrence following hepatectomy

Takashi Motomura, Yuki Ono, Ken Shirabe, Takasuke Fukuhara, Hideyuki Konishi, Yohei Mano, Takeo Toshima, Shohei Yoshiya, Jun Muto, Toru Ikegami, Tomoharu Yoshizumi, Yoshihiko Maehara

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Abstract

Purpose. Genetic polymorphisms of MICA and DEPDC5 have been reported to correlate with progression to hepatocellular carcinoma (HCC) in chronic hepatitis C patients. However, correlation of these genetic variants with HCC recurrence following hepatectomy has not yet been clarified. Methods. Ninety-six consecutive HCC patients who underwent hepatectomy, including 64 patients who were hepatitis C virus (HCV) positive, were genotyped for MICA (rs2596542) and DEPDC5 (rs1012068). Recurrence-free survival rates (RFS) were compared for each genotype. Results. Five-year HCC recurrence-free survival (RFS) rates following hepatectomy were 20.7 in MICA GG allele carriers, 38.7 in GA, and 20.8 in AA, respectively (P = 0.72). The five-year RFS rate was 23.8 in DEPDC5 TT allele carriers and 31.8 in TG/GG, respectively (P = 0.47). The survival rates in all (including HCV-negative) patients were also similar among each MICA and DEPDC5 genotype following hepatectomy. Among HCV-positive patients carrying the DEPDC5 TG/GG allele, low fibrosis stage (F0-2) occurred more often compared with TT carriers (P 0.05). Conclusions. Neither MICA nor DEPDC5 genetic polymorphism correlates with HCC recurrence following hepatectomy. DEPDC5 minor genotype data suggest a high susceptibility for HCC development in livers, even those with low fibrosis stages.

Original languageEnglish
Article number185496
JournalHPB Surgery
Volume2012
DOIs
Publication statusPublished - Nov 30 2012

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Hepatectomy
Genetic Polymorphisms
Hepatocellular Carcinoma
Recurrence
Survival Rate
Hepacivirus
Alleles
Genotype
Fibrosis
Chronic Hepatitis C
Liver

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology

Cite this

Motomura, T., Ono, Y., Shirabe, K., Fukuhara, T., Konishi, H., Mano, Y., ... Maehara, Y. (2012). Neither MICA nor DEPDC5 genetic polymorphisms correlate with hepatocellular carcinoma recurrence following hepatectomy. HPB Surgery, 2012, [185496]. https://doi.org/10.1155/2012/185496

Neither MICA nor DEPDC5 genetic polymorphisms correlate with hepatocellular carcinoma recurrence following hepatectomy. / Motomura, Takashi; Ono, Yuki; Shirabe, Ken; Fukuhara, Takasuke; Konishi, Hideyuki; Mano, Yohei; Toshima, Takeo; Yoshiya, Shohei; Muto, Jun; Ikegami, Toru; Yoshizumi, Tomoharu; Maehara, Yoshihiko.

In: HPB Surgery, Vol. 2012, 185496, 30.11.2012.

Research output: Contribution to journalArticle

Motomura, T, Ono, Y, Shirabe, K, Fukuhara, T, Konishi, H, Mano, Y, Toshima, T, Yoshiya, S, Muto, J, Ikegami, T, Yoshizumi, T & Maehara, Y 2012, 'Neither MICA nor DEPDC5 genetic polymorphisms correlate with hepatocellular carcinoma recurrence following hepatectomy', HPB Surgery, vol. 2012, 185496. https://doi.org/10.1155/2012/185496
Motomura, Takashi ; Ono, Yuki ; Shirabe, Ken ; Fukuhara, Takasuke ; Konishi, Hideyuki ; Mano, Yohei ; Toshima, Takeo ; Yoshiya, Shohei ; Muto, Jun ; Ikegami, Toru ; Yoshizumi, Tomoharu ; Maehara, Yoshihiko. / Neither MICA nor DEPDC5 genetic polymorphisms correlate with hepatocellular carcinoma recurrence following hepatectomy. In: HPB Surgery. 2012 ; Vol. 2012.
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AU - Ono, Yuki

AU - Shirabe, Ken

AU - Fukuhara, Takasuke

AU - Konishi, Hideyuki

AU - Mano, Yohei

AU - Toshima, Takeo

AU - Yoshiya, Shohei

AU - Muto, Jun

AU - Ikegami, Toru

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AU - Maehara, Yoshihiko

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N2 - Purpose. Genetic polymorphisms of MICA and DEPDC5 have been reported to correlate with progression to hepatocellular carcinoma (HCC) in chronic hepatitis C patients. However, correlation of these genetic variants with HCC recurrence following hepatectomy has not yet been clarified. Methods. Ninety-six consecutive HCC patients who underwent hepatectomy, including 64 patients who were hepatitis C virus (HCV) positive, were genotyped for MICA (rs2596542) and DEPDC5 (rs1012068). Recurrence-free survival rates (RFS) were compared for each genotype. Results. Five-year HCC recurrence-free survival (RFS) rates following hepatectomy were 20.7 in MICA GG allele carriers, 38.7 in GA, and 20.8 in AA, respectively (P = 0.72). The five-year RFS rate was 23.8 in DEPDC5 TT allele carriers and 31.8 in TG/GG, respectively (P = 0.47). The survival rates in all (including HCV-negative) patients were also similar among each MICA and DEPDC5 genotype following hepatectomy. Among HCV-positive patients carrying the DEPDC5 TG/GG allele, low fibrosis stage (F0-2) occurred more often compared with TT carriers (P 0.05). Conclusions. Neither MICA nor DEPDC5 genetic polymorphism correlates with HCC recurrence following hepatectomy. DEPDC5 minor genotype data suggest a high susceptibility for HCC development in livers, even those with low fibrosis stages.

AB - Purpose. Genetic polymorphisms of MICA and DEPDC5 have been reported to correlate with progression to hepatocellular carcinoma (HCC) in chronic hepatitis C patients. However, correlation of these genetic variants with HCC recurrence following hepatectomy has not yet been clarified. Methods. Ninety-six consecutive HCC patients who underwent hepatectomy, including 64 patients who were hepatitis C virus (HCV) positive, were genotyped for MICA (rs2596542) and DEPDC5 (rs1012068). Recurrence-free survival rates (RFS) were compared for each genotype. Results. Five-year HCC recurrence-free survival (RFS) rates following hepatectomy were 20.7 in MICA GG allele carriers, 38.7 in GA, and 20.8 in AA, respectively (P = 0.72). The five-year RFS rate was 23.8 in DEPDC5 TT allele carriers and 31.8 in TG/GG, respectively (P = 0.47). The survival rates in all (including HCV-negative) patients were also similar among each MICA and DEPDC5 genotype following hepatectomy. Among HCV-positive patients carrying the DEPDC5 TG/GG allele, low fibrosis stage (F0-2) occurred more often compared with TT carriers (P 0.05). Conclusions. Neither MICA nor DEPDC5 genetic polymorphism correlates with HCC recurrence following hepatectomy. DEPDC5 minor genotype data suggest a high susceptibility for HCC development in livers, even those with low fibrosis stages.

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