Neoadjuvant chemoradiotherapy for clinical stage II-III esophageal squamous cell carcinoma

Hiroshi Saeki, Masaru Morita, Yuichiro Nakashima, Hideto Sonoda, Kenkichi Hashimoto, Akinori Egashira, O. K.I. Eiji, Takefumi Ohga, Yoshihiro Kakeji, Yoshihiko Maehara

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14 Citations (Scopus)

Abstract

Background: The clinical significance of neoadjuvant chemoradiotherapy (NACRT) for potentially resectable esophageal squamous cell carcinoma (ESCC) is unclear. Patients and Methods: Patients with clinical stage II-III ESCC were classified into an NACRT group (n=76) and surgery alone group (n=92). The prognosis and the incidence of postoperative complications were retrospectively investigated. The pathological response to NACRT and patient prognosis were also analyzed. Results: The 5-year survival rate was 47.7% in the surgery alone group and 56.5% in the NACRT group (p=0.4831). The 5-year survival rates of patients in whom NACRT was markedly effective was clearly better than that of the other patients (ineffective/slightly effective: 36.9%, moderately effective: 53.8%, markedly effective: 100%). The incidence of postoperative complications was 31.5% in the surgery alone group and 40.8% in the NACRT group (p=0.2121). Conclusion: A pathological complete response to NACRT is critical for improving the survival of patients with clinical stageII-III ESCC.

Original languageEnglish
Pages (from-to)3073-3077
Number of pages5
JournalAnticancer research
Volume31
Issue number9
Publication statusPublished - Sep 1 2011

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Saeki, H., Morita, M., Nakashima, Y., Sonoda, H., Hashimoto, K., Egashira, A., Eiji, O. K. I., Ohga, T., Kakeji, Y., & Maehara, Y. (2011). Neoadjuvant chemoradiotherapy for clinical stage II-III esophageal squamous cell carcinoma. Anticancer research, 31(9), 3073-3077.