Neostriatal evoked inhibition and effects of dopamine on globus pallidal neurons in rat slice preparations

Hiroshi Nakanishi, Nobuaki Hori, Nobuo Kastuda

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Spontaneous unit discharges were recorded extracellularly from globus pallidal (GP) neurons in rat slice preparations. The firing rates of GP neurons ranged from 2.0 to 24.0 spikes/s and their firing patterns were predominantly of two types: regular and irregular. Stimulation of the neostriatum evoked two distinct types of inhibition which were dependent on GP neuronal firing patterns, a brief inhibition (about 75 ms) followed by resetting rhythmic neuronal activities and a relatively long-term inhibition (about 100 ms). These inhibitions evoked by neostriatal stimulation were attenuated or completely blocked by bath application of either bicuculline of strychnine (2 × 10-5-10-4M) but not by a naloxone. Bath application of dopamine (10-4-10 -3M) produced slow increases in the firing rates by 30-65% in about a half of GP neurons tested. Iontophoretic application of dopamine (10-20 nA) attenuated inhibition in GP neurons by 40-55% induced by either iontophoretically applied GABA (5-30 nA) or neostriatal stimulation without affecting their spontaneous firings. These results suggest that dopamine may produce change in the firing patterns of GP neurons by either acting directly or attenuating GABAergic inhibitory transmission from the neostriatum.

Original languageEnglish
Pages (from-to)282-286
Number of pages5
JournalBrain Research
Volume358
Issue number1-2
DOIs
Publication statusPublished - Dec 9 1985

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Dopamine
Neurons
Neostriatum
Baths
Strychnine
Bicuculline
Naloxone
gamma-Aminobutyric Acid

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Neostriatal evoked inhibition and effects of dopamine on globus pallidal neurons in rat slice preparations. / Nakanishi, Hiroshi; Hori, Nobuaki; Kastuda, Nobuo.

In: Brain Research, Vol. 358, No. 1-2, 09.12.1985, p. 282-286.

Research output: Contribution to journalArticle

Nakanishi, Hiroshi ; Hori, Nobuaki ; Kastuda, Nobuo. / Neostriatal evoked inhibition and effects of dopamine on globus pallidal neurons in rat slice preparations. In: Brain Research. 1985 ; Vol. 358, No. 1-2. pp. 282-286.
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