Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics

Joonho Choi, Hyung Jun Yoon, Jae Hong Park, Yukako Nakagami, Chika Kubota, Toshiya Inada, Takahiro A. Kato, Shu Yu Yang, Sih Ku Lin, Mian Yoon Chong, Ajit Avasthi, Sandeep Grover, Roy Abraham Kallivayalil, Andi Jaylangkara Tanra, Kok Yoon Chee, Yu Tao Xiang, Kang Sim, Afzal Javed, Chay Hoon Tan, Norman SartoriusShigenobu Kanba, Naotaka Shinfuku, Yong Chon Park, Seon Cheol Park

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The symptom heterogeneity of schizophrenia is consistent with Wittgenstein’s analogy of a language game. From the perspective of precision medicine, this study aimed to estimate the symptom presentation and identify the psychonectome in Asian patients, using data obtained from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics. We constructed a network structure of the Brief Psychiatric Rating Scale (BPRS) items in 1438 Asian patients with schizophrenia. Furthermore, all the BPRS items were considered to be an ordered categorical variable ranging in value from 1–7. Motor retardation was situated most centrally within the BPRS network structure, followed by depressive mood and unusual thought content. Contrastingly, hallucinatory behavior was situated least centrally within the network structure. Using a community detection algorithm, the BPRS items were organized into positive, negative, and general symptom clusters. Overall, DSM symptoms were not more central than non-DSM symptoms within the symptom network of Asian patients with schizophrenia. Thus, motor retardation, which results from the unmet needs associated with current antipsychotic medications for schizophrenia, may be a tailored treatment target for Asian patients with schizophrenia. Based on these findings, targeting non-dopamine systems (glutamate, γ-aminobutyric acid) may represent an effective strategy with respect to precision medicine for psychosis.

Original languageEnglish
Article number33
JournalJournal of Personalized Medicine
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2022

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

Fingerprint

Dive into the research topics of 'Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics'. Together they form a unique fingerprint.

Cite this