Neural damage associated with allergic diseases: Pathomechanism and therapy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We disclosed the occurrences of myelitis with atopic diathesis preferentially affecting the cervical spinal cord in Japan. Recent nationwide survey revealed that this condition occurs throughout Japan. The characteristic features are: (1) young to middle-aged adults with atopic diathesis are affected, (2) stepwise progression and fluctuation of the symptoms are frequent, (3) paresthesia and dysesthesia are the initial and predominant symptoms while severe motor weakness is rare, (4) CSF abnormalities are infrequent and mild, (5) hyperIgEaemia and mite antigen-specific IgE are present in most cases and eosinophilia is present in about half cases, (6) cervical spinal cord is affected most frequently by clinical symptomatology and on MRI. In this condition, plasma exchange is beneficial in about 80% while corticosteoids are effective only in 50%. The spinal cord biopsy specimens demonstrated its neuropathology to be eosinophilic myelitis involving myelin as well as axon. We also found that Hirayama disease is associated with airway allergy such as allergic rhinitis and atopic asthma. In children, poliomyelitis-like illness after acute asthma attacks is well known as Hopkins syndrome. These findings strongly suggest a link between atopic diathesis and spinal cord damage.

Original languageEnglish
Pages (from-to)756-760
Number of pages5
JournalClinical Neurology
Volume43
Issue number11
Publication statusPublished - Nov 1 2003

Fingerprint

Disease Susceptibility
Myelitis
Paresthesia
Spinal Cord
Japan
Asthma
Plasma Exchange
Mites
Eosinophilia
Poliomyelitis
Myelin Sheath
Immunoglobulin E
Axons
Hypersensitivity
Therapeutics
Biopsy
Antigens
Cervical Cord

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Neural damage associated with allergic diseases : Pathomechanism and therapy. / Kira, Jun Ichi.

In: Clinical Neurology, Vol. 43, No. 11, 01.11.2003, p. 756-760.

Research output: Contribution to journalArticle

@article{8bdb4f5be4ab46dab0d5a9b80ae4d9ac,
title = "Neural damage associated with allergic diseases: Pathomechanism and therapy",
abstract = "We disclosed the occurrences of myelitis with atopic diathesis preferentially affecting the cervical spinal cord in Japan. Recent nationwide survey revealed that this condition occurs throughout Japan. The characteristic features are: (1) young to middle-aged adults with atopic diathesis are affected, (2) stepwise progression and fluctuation of the symptoms are frequent, (3) paresthesia and dysesthesia are the initial and predominant symptoms while severe motor weakness is rare, (4) CSF abnormalities are infrequent and mild, (5) hyperIgEaemia and mite antigen-specific IgE are present in most cases and eosinophilia is present in about half cases, (6) cervical spinal cord is affected most frequently by clinical symptomatology and on MRI. In this condition, plasma exchange is beneficial in about 80{\%} while corticosteoids are effective only in 50{\%}. The spinal cord biopsy specimens demonstrated its neuropathology to be eosinophilic myelitis involving myelin as well as axon. We also found that Hirayama disease is associated with airway allergy such as allergic rhinitis and atopic asthma. In children, poliomyelitis-like illness after acute asthma attacks is well known as Hopkins syndrome. These findings strongly suggest a link between atopic diathesis and spinal cord damage.",
author = "Kira, {Jun Ichi}",
year = "2003",
month = "11",
day = "1",
language = "English",
volume = "43",
pages = "756--760",
journal = "Clinical Neurology",
issn = "0009-918X",
publisher = "Societas Neurologica Japonica",
number = "11",

}

TY - JOUR

T1 - Neural damage associated with allergic diseases

T2 - Pathomechanism and therapy

AU - Kira, Jun Ichi

PY - 2003/11/1

Y1 - 2003/11/1

N2 - We disclosed the occurrences of myelitis with atopic diathesis preferentially affecting the cervical spinal cord in Japan. Recent nationwide survey revealed that this condition occurs throughout Japan. The characteristic features are: (1) young to middle-aged adults with atopic diathesis are affected, (2) stepwise progression and fluctuation of the symptoms are frequent, (3) paresthesia and dysesthesia are the initial and predominant symptoms while severe motor weakness is rare, (4) CSF abnormalities are infrequent and mild, (5) hyperIgEaemia and mite antigen-specific IgE are present in most cases and eosinophilia is present in about half cases, (6) cervical spinal cord is affected most frequently by clinical symptomatology and on MRI. In this condition, plasma exchange is beneficial in about 80% while corticosteoids are effective only in 50%. The spinal cord biopsy specimens demonstrated its neuropathology to be eosinophilic myelitis involving myelin as well as axon. We also found that Hirayama disease is associated with airway allergy such as allergic rhinitis and atopic asthma. In children, poliomyelitis-like illness after acute asthma attacks is well known as Hopkins syndrome. These findings strongly suggest a link between atopic diathesis and spinal cord damage.

AB - We disclosed the occurrences of myelitis with atopic diathesis preferentially affecting the cervical spinal cord in Japan. Recent nationwide survey revealed that this condition occurs throughout Japan. The characteristic features are: (1) young to middle-aged adults with atopic diathesis are affected, (2) stepwise progression and fluctuation of the symptoms are frequent, (3) paresthesia and dysesthesia are the initial and predominant symptoms while severe motor weakness is rare, (4) CSF abnormalities are infrequent and mild, (5) hyperIgEaemia and mite antigen-specific IgE are present in most cases and eosinophilia is present in about half cases, (6) cervical spinal cord is affected most frequently by clinical symptomatology and on MRI. In this condition, plasma exchange is beneficial in about 80% while corticosteoids are effective only in 50%. The spinal cord biopsy specimens demonstrated its neuropathology to be eosinophilic myelitis involving myelin as well as axon. We also found that Hirayama disease is associated with airway allergy such as allergic rhinitis and atopic asthma. In children, poliomyelitis-like illness after acute asthma attacks is well known as Hopkins syndrome. These findings strongly suggest a link between atopic diathesis and spinal cord damage.

UR - http://www.scopus.com/inward/record.url?scp=3042688054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042688054&partnerID=8YFLogxK

M3 - Article

C2 - 15152457

AN - SCOPUS:3042688054

VL - 43

SP - 756

EP - 760

JO - Clinical Neurology

JF - Clinical Neurology

SN - 0009-918X

IS - 11

ER -