Neural progenitors are direct targets of xenoestrogens in zebrafish

Olivier Kah, Yann Le Page, Mélanie Vosges, Sok Keng Tong, Bon Chu Chung, François Brion

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Because a large proportion of endocrine disruptor chemicals (EDC) end up in surface waters, aquatic species are particularly vulnerable to their potential effects. In this regard, fish populations must be carefully monitored for fishes are absolutely crucial in terms of biodiversity and protein resources, but also they are extremely valuable as sentinel species. In this chapter, we discuss EDCs effects on the brain of fish, in particular on radial glial cells, which in all vertebrate species are brain stem cells. Indeed, one of the most prominent effect of EDCs in zebrafish is their impact on the cyp19a1b gene that encodes aromatase B. Strikingly, aromatase B is only expressed in radial glial cells that behave as neuronal progenitors. Detailed molecular and whole animal studies in transgenic zebrafish demonstrated the extreme sensitivity of the cyp19a1b gene to estrogen mimics. In particular, doses as low as 1.5 ng/L of EE2 were consistently shown to turn on cyp19a1b gene expression in 2-5 days old zebrafish embryos. As recent studies indicate that estrogens modulate proliferative activity of radial glia progenitors, it is likely that estrogen mimics may have similar activity. The potential outcome of such effects requires thorough investigations, not only in fish but also in developing mammals. In addition, those studies have led to the development of a very sensitive in vivo assay that makes use of cyp19a1b-GFP transgenic embryos whose brain exhibits GFP expression if exposed to any estrogen mimic acting through estrogen receptors.

Original languageEnglish
Title of host publicationMulti-System Endocrine Disruption
Pages73-89
Number of pages17
DOIs
Publication statusPublished - Dec 1 2011

Publication series

NameResearch and Perspectives in Endocrine Interactions
Volume10
ISSN (Print)1861-2253

Fingerprint

Zebrafish
Estrogens
Fishes
Ependymoglial Cells
Aromatase
Embryonic Structures
Endocrine Disruptors
Biodiversity
Brain
Neuroglia
Estrogen Receptors
Genes
Brain Stem
Vertebrates
Mammals
Stem Cells
Gene Expression
Water
Population
Proteins

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kah, O., Le Page, Y., Vosges, M., Tong, S. K., Chung, B. C., & Brion, F. (2011). Neural progenitors are direct targets of xenoestrogens in zebrafish. In Multi-System Endocrine Disruption (pp. 73-89). (Research and Perspectives in Endocrine Interactions; Vol. 10). https://doi.org/10.1007/978-3-642-22775-2_5

Neural progenitors are direct targets of xenoestrogens in zebrafish. / Kah, Olivier; Le Page, Yann; Vosges, Mélanie; Tong, Sok Keng; Chung, Bon Chu; Brion, François.

Multi-System Endocrine Disruption. 2011. p. 73-89 (Research and Perspectives in Endocrine Interactions; Vol. 10).

Research output: Chapter in Book/Report/Conference proceedingChapter

Kah, O, Le Page, Y, Vosges, M, Tong, SK, Chung, BC & Brion, F 2011, Neural progenitors are direct targets of xenoestrogens in zebrafish. in Multi-System Endocrine Disruption. Research and Perspectives in Endocrine Interactions, vol. 10, pp. 73-89. https://doi.org/10.1007/978-3-642-22775-2_5
Kah O, Le Page Y, Vosges M, Tong SK, Chung BC, Brion F. Neural progenitors are direct targets of xenoestrogens in zebrafish. In Multi-System Endocrine Disruption. 2011. p. 73-89. (Research and Perspectives in Endocrine Interactions). https://doi.org/10.1007/978-3-642-22775-2_5
Kah, Olivier ; Le Page, Yann ; Vosges, Mélanie ; Tong, Sok Keng ; Chung, Bon Chu ; Brion, François. / Neural progenitors are direct targets of xenoestrogens in zebrafish. Multi-System Endocrine Disruption. 2011. pp. 73-89 (Research and Perspectives in Endocrine Interactions).
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