Neural regulation of blood pressure by leptin and the related peptides

Kiyoshi Matsumura, Takuya Tsuchihashi, Koji Fujii, Mitsuo Iida

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

Recent biological advances make it possible to discover new peptides associated with obesity. Leptin, neuropeptide Y, corticotrophin-releasing factor (CRF), α-melanocyte stimulating hormone (α-MSH), and cocaine- and amphetamine-regulated transcript (CART) peptides are known to participate in appetite and feeding behavior. Various lines of evidence suggest that these peptides participate not only in feeding behavior but also in cardiovascular and sympathetic regulations. Both leptin and ghrelin are secreted from the peripheral tissue; then they reach the brain to modulate sympathetic activity. These two peptides seem to play important roles to transmit peripheral metabolic information to the brain, and to convert it to cardiovascular and sympathetic information. Leptin activates neurons containing α-melanocyte stimulating hormone and cocaine- and amphetamine-regulated transcript peptides, resulting in increases in sympathetic activity and blood pressure. Cardiovascular action of α-melanocyte stimulating hormone is mediated through melanocortin-4 receptor, and agouti-related protein (AGRP) plays a role as an endogenous melanocortin-4 receptor antagonist. In contrast, ghrelin and neuropeptide Y in the brain suppress sympathetic activity and decrease blood pressure. Depressor and sympathoinhibitory effects of central neuropeptide Y are inhibited by leptin. Furthermore, central ghrelin modulates baroreflex control of renal sympathetic nerve activity and heart rate. Thus, leptin and the related peptides, which participate in appetite and feeding behavior, seem to function together to regulate cardiovascular system and sympathetic nerve activity, and may play a key role in the association between obesity and hypertension.

Original languageEnglish
Pages (from-to)79-86
Number of pages8
JournalRegulatory Peptides
Volume114
Issue number2-3
DOIs
Publication statusPublished - Jul 15 2003

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Blood pressure
Leptin
Blood Pressure
Melanocyte-Stimulating Hormones
Peptides
Ghrelin
Neuropeptide Y
Feeding Behavior
Receptor, Melanocortin, Type 4
Brain
Appetite
Amphetamine
Cocaine
Agouti-Related Protein
Obesity
Cardiovascular system
Baroreflex
Corticotropin-Releasing Hormone
Cardiovascular System
Neurons

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Neural regulation of blood pressure by leptin and the related peptides. / Matsumura, Kiyoshi; Tsuchihashi, Takuya; Fujii, Koji; Iida, Mitsuo.

In: Regulatory Peptides, Vol. 114, No. 2-3, 15.07.2003, p. 79-86.

Research output: Contribution to journalReview article

Matsumura, K, Tsuchihashi, T, Fujii, K & Iida, M 2003, 'Neural regulation of blood pressure by leptin and the related peptides', Regulatory Peptides, vol. 114, no. 2-3, pp. 79-86. https://doi.org/10.1016/S0167-0115(03)00116-2
Matsumura, Kiyoshi ; Tsuchihashi, Takuya ; Fujii, Koji ; Iida, Mitsuo. / Neural regulation of blood pressure by leptin and the related peptides. In: Regulatory Peptides. 2003 ; Vol. 114, No. 2-3. pp. 79-86.
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