Neural stem cell therapy aiming at better functional recovery after spinal cord injury

Yicheng Zhu, Naohiro Uezono, Tetsuro Yasui, Kinichi Nakashima

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Injury to the spinal cord causes transection of axon fibers and neural cell death, resulting in disruption of the neural network and severe functional loss. Reconstruction of the damaged neural circuits was once considered to be hopeless as the adult mammalian central nervous system has very poor ability to regenerate. For this reason, there is currently no effective therapeutic treatment for spinal cord injury (SCI). However, with recent developments in stem cell research and cell culture technology, regenerative therapy using neural stem cell (NSC) transplantation has rapidly been developed, and this therapeutic strategy makes it possible to rebuild the destroyed neural circuits. In this review, we discuss the recent breakthroughs in NSC transplantation therapy for SCI. Developmental Dynamics 247:75–84, 2018.

Original languageEnglish
Pages (from-to)75-84
Number of pages10
JournalDevelopmental Dynamics
Volume247
Issue number1
DOIs
Publication statusPublished - Jan 2018

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Neural Stem Cells
Cell- and Tissue-Based Therapy
Spinal Cord Injuries
Stem Cell Transplantation
Stem Cell Research
Therapeutics
Axons
Cell Death
Central Nervous System
Cell Culture Techniques
Technology
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Cite this

Neural stem cell therapy aiming at better functional recovery after spinal cord injury. / Zhu, Yicheng; Uezono, Naohiro; Yasui, Tetsuro; Nakashima, Kinichi.

In: Developmental Dynamics, Vol. 247, No. 1, 01.2018, p. 75-84.

Research output: Contribution to journalReview article

Zhu, Yicheng ; Uezono, Naohiro ; Yasui, Tetsuro ; Nakashima, Kinichi. / Neural stem cell therapy aiming at better functional recovery after spinal cord injury. In: Developmental Dynamics. 2018 ; Vol. 247, No. 1. pp. 75-84.
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