Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. ingens (Thiele, 1899)

Bo Zhang; Ryuichi Higuchi; Tomofumi Miyamoto; Rob W.M. Van Soest

doi:10.1248/cpb.56.866

Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. ingens (Thiele, 1899)

Bo Zhang, Ryuichi Higuchi, Tomofumi Miyamoto, Rob W.M. Van Soest

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Two manzamine-class alkaloids, manzamine A (1) and 8-hydroxymanzamine (2) were isolated from a Japanese marine sponge Acanthostrongylophora aff. ingens, together with three known alkaloids manzamine E (3), manzamine F (4), and manzamine X (5). The spectral features of 1 and 2 were different from the reported data. Detailed structure analysis using 2D NMR revealed the structure of 1 and 2 as a free base form of hydrochloric salt. These manzamine-class alkaloids showed neuritogenic activity against Neuro 2a cells.

Original language	English
Pages (from-to)	866-869
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	56
Issue number	6
DOIs	https://doi.org/10.1248/cpb.56.866
Publication status	Published - Jun 2008

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Chemistry(all)
Drug Discovery

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AU - Van Soest, Rob W.M.

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Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. ingens (Thiele, 1899)

Abstract

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