Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. ingens (Thiele, 1899)

Bo Zhang, Ryuichi Higuchi, Tomofumi Miyamoto, Rob W.M. Van Soest

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15 Citations (Scopus)


Two manzamine-class alkaloids, manzamine A (1) and 8-hydroxymanzamine (2) were isolated from a Japanese marine sponge Acanthostrongylophora aff. ingens, together with three known alkaloids manzamine E (3), manzamine F (4), and manzamine X (5). The spectral features of 1 and 2 were different from the reported data. Detailed structure analysis using 2D NMR revealed the structure of 1 and 2 as a free base form of hydrochloric salt. These manzamine-class alkaloids showed neuritogenic activity against Neuro 2a cells.

Original languageEnglish
Pages (from-to)866-869
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Issue number6
Publication statusPublished - Jun 1 2008


All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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