Neuritogenic and neuroprotective constituents from Aquilaria crassna leaves

Chonlakan Supasuteekul, Sarin Tadtong, Waraporn Putalun, Hiroyuki Tanaka, Kittisak Likhitwitayawuid, Parkpoom Tengamnuay, Boonchoo Sritularak

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The leaves of Aquilaria crassna (Thymelaeaceae) are recently become an attractive research due to their potential in antioxidative, antibacterial, antipyretic, analgesic, and laxative activities. However, the neuritogenic and neuroprotective effects of A. crassna leaves have never been reported. In this study, three phenolic glycosides were isolated from A. crassna leaves. The isolates were identified as genkwanin 5-O-β-primevoside (1), iriflophenone 3,5-C-β-d-diglucoside (2) and iriflophenone 3-C-β-d-glucoside (3). The neuroprotective and neuritogenic activities of these compounds were evaluated. Compound 1 and 2, at very low concentration (100 ng/mL of compound 1 and 1 ng/mL of compound 2), exhibited the protection of P19-derived neurons and promoted the neurite outgrowth of the cultured neurons. In addition, a preliminary study on these compounds revealed that there was no correlation between their antioxidative properties and their neuroprotective activities. Practical applications: Agarwood leaves have been used as an ingredient in foods and drinks for health promotion in Asian countries. The results of this study also suggest that Aquilaria crassna leaves are potentially sources of neuritogenic and neuroprotective constituents, which may be developed as functional foods for the prevention of neurodegenerative disorder.

Original languageEnglish
Article numbere12365
JournalJournal of Food Biochemistry
Volume41
Issue number3
DOIs
Publication statusPublished - Jun 2017

Fingerprint

Thymelaeaceae
neuroprotective effect
Neurons
leaves
Antipyretics
Laxatives
Functional Food
Glucosides
Neuroprotective Agents
Glycosides
Health Promotion
Neurodegenerative Diseases
neurons
Analgesics
antipyretics
laxatives
health promotion
neurites
neurodegenerative diseases
analgesics

All Science Journal Classification (ASJC) codes

  • Food Science
  • Biophysics
  • Pharmacology
  • Cell Biology

Cite this

Supasuteekul, C., Tadtong, S., Putalun, W., Tanaka, H., Likhitwitayawuid, K., Tengamnuay, P., & Sritularak, B. (2017). Neuritogenic and neuroprotective constituents from Aquilaria crassna leaves. Journal of Food Biochemistry, 41(3), [e12365]. https://doi.org/10.1111/jfbc.12365

Neuritogenic and neuroprotective constituents from Aquilaria crassna leaves. / Supasuteekul, Chonlakan; Tadtong, Sarin; Putalun, Waraporn; Tanaka, Hiroyuki; Likhitwitayawuid, Kittisak; Tengamnuay, Parkpoom; Sritularak, Boonchoo.

In: Journal of Food Biochemistry, Vol. 41, No. 3, e12365, 06.2017.

Research output: Contribution to journalArticle

Supasuteekul, C, Tadtong, S, Putalun, W, Tanaka, H, Likhitwitayawuid, K, Tengamnuay, P & Sritularak, B 2017, 'Neuritogenic and neuroprotective constituents from Aquilaria crassna leaves', Journal of Food Biochemistry, vol. 41, no. 3, e12365. https://doi.org/10.1111/jfbc.12365
Supasuteekul C, Tadtong S, Putalun W, Tanaka H, Likhitwitayawuid K, Tengamnuay P et al. Neuritogenic and neuroprotective constituents from Aquilaria crassna leaves. Journal of Food Biochemistry. 2017 Jun;41(3). e12365. https://doi.org/10.1111/jfbc.12365
Supasuteekul, Chonlakan ; Tadtong, Sarin ; Putalun, Waraporn ; Tanaka, Hiroyuki ; Likhitwitayawuid, Kittisak ; Tengamnuay, Parkpoom ; Sritularak, Boonchoo. / Neuritogenic and neuroprotective constituents from Aquilaria crassna leaves. In: Journal of Food Biochemistry. 2017 ; Vol. 41, No. 3.
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