Neuroanatomical substrate of chronic psychosis in epilepsy

an MRI study

Noriaki Hirakawa, Hironori Kuga, Yoji Hirano, Jinya Sato, Naoya Oribe, Itta Nakamura, Shogo Hirano, Takefumi Ueno, Yuko Oda, Osamu Togao, Hiwatashi Akio, Hiroshi Honda, Shigenobu Kanba, Toshiaki Onitsuka

Research output: Contribution to journalArticle

Abstract

There may be different neural bases between subjects with epilepsy only (EP) and interictal chronic epilepsy psychosis (EPS). However, there have been few structural MRI studies of EPS. The current study was conducted to investigate the neural substrate of EPS. T1-weighted images were analyzed in 14 patients with EPS and 14 strictly-matched patients with EP. We conducted volume comparison in the whole brain using voxel-based morphometry (VBM). The VBM method revealed that EPS patients exhibited significantly reduced gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus compared with EP patients (adjusted p = 0.029, FDR corrected q; k = 319 voxels). For clinical correlations, there were no significant associations between psychotic symptoms and gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus. VBM analysis revealed that reduced gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus may be crucial regions for EPS.

Original languageEnglish
JournalBrain Imaging and Behavior
DOIs
Publication statusPublished - Jan 1 2019

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Psychotic Disorders
Epilepsy
Somatosensory Cortex
Prefrontal Cortex
Brain
Gray Matter

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Neuroanatomical substrate of chronic psychosis in epilepsy : an MRI study. / Hirakawa, Noriaki; Kuga, Hironori; Hirano, Yoji; Sato, Jinya; Oribe, Naoya; Nakamura, Itta; Hirano, Shogo; Ueno, Takefumi; Oda, Yuko; Togao, Osamu; Akio, Hiwatashi; Honda, Hiroshi; Kanba, Shigenobu; Onitsuka, Toshiaki.

In: Brain Imaging and Behavior, 01.01.2019.

Research output: Contribution to journalArticle

Hirakawa, Noriaki ; Kuga, Hironori ; Hirano, Yoji ; Sato, Jinya ; Oribe, Naoya ; Nakamura, Itta ; Hirano, Shogo ; Ueno, Takefumi ; Oda, Yuko ; Togao, Osamu ; Akio, Hiwatashi ; Honda, Hiroshi ; Kanba, Shigenobu ; Onitsuka, Toshiaki. / Neuroanatomical substrate of chronic psychosis in epilepsy : an MRI study. In: Brain Imaging and Behavior. 2019.
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