Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice

Jae Sung Bae, Shigeki Furuya, Yoko Shinoda, Shogo Endo, Edward H. Schuchman, Yoshio Hirabayashi, Hee Kyung Jin

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

After transplantation, adult bone marrow-derived mesenchymal stem cells (BM-MSCs) may undergo transdifferentiation and/or cell fusion in response to new environments. However, the mechanism(s) that govern these cell fate switches remain unknown. Here we demonstrate that the pathology associated with murine Niemann-Pick disease type C (NP-C) cerebellum augments the ability of BM-MSCs to fuse with Purkinje neurons. The results suggest that the degenerative microenvironment of Purkinje neurons in the NP-C cerebellum modulates the cell fate switch of BM-MSCs via cell fusion.

Original languageEnglish
Pages (from-to)1006-1011
Number of pages6
JournalHuman Gene Therapy
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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