Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice

Jae Sung Bae, Shigeki Furuya, Yoko Shinoda, Shogo Endo, Edward H. Schuchman, Yoshio Hirabayashi, Hee Kyung Jin

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

After transplantation, adult bone marrow-derived mesenchymal stem cells (BM-MSCs) may undergo transdifferentiation and/or cell fusion in response to new environments. However, the mechanism(s) that govern these cell fate switches remain unknown. Here we demonstrate that the pathology associated with murine Niemann-Pick disease type C (NP-C) cerebellum augments the ability of BM-MSCs to fuse with Purkinje neurons. The results suggest that the degenerative microenvironment of Purkinje neurons in the NP-C cerebellum modulates the cell fate switch of BM-MSCs via cell fusion.

Original languageEnglish
Pages (from-to)1006-1011
Number of pages6
JournalHuman Gene Therapy
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 1 2005
Externally publishedYes

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Purkinje Cells
Mesenchymal Stromal Cells
Cell Fusion
Bone Marrow
Cerebellum
Type C Niemann-Pick Disease
Transplantation
Pathology

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice. / Bae, Jae Sung; Furuya, Shigeki; Shinoda, Yoko; Endo, Shogo; Schuchman, Edward H.; Hirabayashi, Yoshio; Jin, Hee Kyung.

In: Human Gene Therapy, Vol. 16, No. 8, 01.08.2005, p. 1006-1011.

Research output: Contribution to journalArticle

Bae, Jae Sung ; Furuya, Shigeki ; Shinoda, Yoko ; Endo, Shogo ; Schuchman, Edward H. ; Hirabayashi, Yoshio ; Jin, Hee Kyung. / Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice. In: Human Gene Therapy. 2005 ; Vol. 16, No. 8. pp. 1006-1011.
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