Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells

Jae Sung Bae; Shigeki Furuya; So Jeo Ahn; Seong Joon Yi; Yoshio Hirabayashi; Hee Kyung Jin

doi:10.1016/j.neulet.2005.02.029

Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells

Jae Sung Bae, Shigeki Furuya, So Jeo Ahn, Seong Joon Yi, Yoshio Hirabayashi, Hee Kyung Jin

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Abstract

Glial activation is thought to play a key role in pathogenesis of neurodegenerative disorders. Here we show that direct transplantation of bone marrow-derived mesenchymal stem cells (BM-MSC) results in alleviation of inflammatory responses associated with the cerebellum of Niemann-Pick disease Type C (NP-C) model mice. Immunohistochemical examinations using glial fibrillary acidic protein (GFAP) and F4/80 antibodies revealed that BM-MSC transplantation reduced significantly both of astocytic and microglial activations in the cerebellum of NP-C mice. Expression of macrophage colony stimulating factor (M-CSF), a microglial activator, was also considerably down-regulated by the BM-MSC transplantation. These findings suggest that BM-MSC transplantation may have potential for a therapeutic role in the treatment of NP-C and other neurodegenerative brain disorders.

Original language	English
Pages (from-to)	234-236
Number of pages	3
Journal	Neuroscience Letters
Volume	381
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2005.02.029
Publication status	Published - Jun 24 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1016/j.neulet.2005.02.029

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title = "Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells",

abstract = "Glial activation is thought to play a key role in pathogenesis of neurodegenerative disorders. Here we show that direct transplantation of bone marrow-derived mesenchymal stem cells (BM-MSC) results in alleviation of inflammatory responses associated with the cerebellum of Niemann-Pick disease Type C (NP-C) model mice. Immunohistochemical examinations using glial fibrillary acidic protein (GFAP) and F4/80 antibodies revealed that BM-MSC transplantation reduced significantly both of astocytic and microglial activations in the cerebellum of NP-C mice. Expression of macrophage colony stimulating factor (M-CSF), a microglial activator, was also considerably down-regulated by the BM-MSC transplantation. These findings suggest that BM-MSC transplantation may have potential for a therapeutic role in the treatment of NP-C and other neurodegenerative brain disorders.",

author = "Bae, {Jae Sung} and Shigeki Furuya and Ahn, {So Jeo} and Yi, {Seong Joon} and Yoshio Hirabayashi and Jin, {Hee Kyung}",

note = "Funding Information: We wish to thank Prof. Kousaku Ohno and Dr. Haruaki Ninomiya of Tottori University Medical School for providing BALB/c npc nih mice. The authors thank Jong-kil Lee, Sung-il Kim, and Han-byung Yoon for technical assistance. This work was supported by Korea Research Foundation Grant no. KRF-2003-003-E00244.",

year = "2005",

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doi = "10.1016/j.neulet.2005.02.029",

language = "English",

volume = "381",

pages = "234--236",

journal = "Neuroscience Letters",

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T1 - Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells

AU - Bae, Jae Sung

AU - Furuya, Shigeki

AU - Ahn, So Jeo

AU - Yi, Seong Joon

AU - Hirabayashi, Yoshio

AU - Jin, Hee Kyung

N1 - Funding Information: We wish to thank Prof. Kousaku Ohno and Dr. Haruaki Ninomiya of Tottori University Medical School for providing BALB/c npc nih mice. The authors thank Jong-kil Lee, Sung-il Kim, and Han-byung Yoon for technical assistance. This work was supported by Korea Research Foundation Grant no. KRF-2003-003-E00244.

PY - 2005/6/24

Y1 - 2005/6/24

N2 - Glial activation is thought to play a key role in pathogenesis of neurodegenerative disorders. Here we show that direct transplantation of bone marrow-derived mesenchymal stem cells (BM-MSC) results in alleviation of inflammatory responses associated with the cerebellum of Niemann-Pick disease Type C (NP-C) model mice. Immunohistochemical examinations using glial fibrillary acidic protein (GFAP) and F4/80 antibodies revealed that BM-MSC transplantation reduced significantly both of astocytic and microglial activations in the cerebellum of NP-C mice. Expression of macrophage colony stimulating factor (M-CSF), a microglial activator, was also considerably down-regulated by the BM-MSC transplantation. These findings suggest that BM-MSC transplantation may have potential for a therapeutic role in the treatment of NP-C and other neurodegenerative brain disorders.

AB - Glial activation is thought to play a key role in pathogenesis of neurodegenerative disorders. Here we show that direct transplantation of bone marrow-derived mesenchymal stem cells (BM-MSC) results in alleviation of inflammatory responses associated with the cerebellum of Niemann-Pick disease Type C (NP-C) model mice. Immunohistochemical examinations using glial fibrillary acidic protein (GFAP) and F4/80 antibodies revealed that BM-MSC transplantation reduced significantly both of astocytic and microglial activations in the cerebellum of NP-C mice. Expression of macrophage colony stimulating factor (M-CSF), a microglial activator, was also considerably down-regulated by the BM-MSC transplantation. These findings suggest that BM-MSC transplantation may have potential for a therapeutic role in the treatment of NP-C and other neurodegenerative brain disorders.

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Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells

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