Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells

Jae Sung Bae, Shigeki Furuya, So Jeo Ahn, Seong Joon Yi, Yoshio Hirabayashi, Hee Kyung Jin

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Glial activation is thought to play a key role in pathogenesis of neurodegenerative disorders. Here we show that direct transplantation of bone marrow-derived mesenchymal stem cells (BM-MSC) results in alleviation of inflammatory responses associated with the cerebellum of Niemann-Pick disease Type C (NP-C) model mice. Immunohistochemical examinations using glial fibrillary acidic protein (GFAP) and F4/80 antibodies revealed that BM-MSC transplantation reduced significantly both of astocytic and microglial activations in the cerebellum of NP-C mice. Expression of macrophage colony stimulating factor (M-CSF), a microglial activator, was also considerably down-regulated by the BM-MSC transplantation. These findings suggest that BM-MSC transplantation may have potential for a therapeutic role in the treatment of NP-C and other neurodegenerative brain disorders.

Original languageEnglish
Pages (from-to)234-236
Number of pages3
JournalNeuroscience Letters
Volume381
Issue number3
DOIs
Publication statusPublished - Jun 24 2005

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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