Abstract
Glial activation is thought to play a key role in pathogenesis of neurodegenerative disorders. Here we show that direct transplantation of bone marrow-derived mesenchymal stem cells (BM-MSC) results in alleviation of inflammatory responses associated with the cerebellum of Niemann-Pick disease Type C (NP-C) model mice. Immunohistochemical examinations using glial fibrillary acidic protein (GFAP) and F4/80 antibodies revealed that BM-MSC transplantation reduced significantly both of astocytic and microglial activations in the cerebellum of NP-C mice. Expression of macrophage colony stimulating factor (M-CSF), a microglial activator, was also considerably down-regulated by the BM-MSC transplantation. These findings suggest that BM-MSC transplantation may have potential for a therapeutic role in the treatment of NP-C and other neurodegenerative brain disorders.
Original language | English |
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Pages (from-to) | 234-236 |
Number of pages | 3 |
Journal | Neuroscience Letters |
Volume | 381 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jun 24 2005 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Neuroscience(all)